PMID- 29945425
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 15
IP  - 8
DP  - 2018 Aug
TI  - Alterations in Serum BDNF and GDNF Levels after 12 Weeks of Antidepressant 
      Treatment in Female Outpatients with Major Depressive Disorder.
PG  - 818-823
LID - 10.30773/pi.2018.03.31 [doi]
AB  - OBJECTIVE: Some clinical studies have found alterations in the levels of serum 
      brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic 
      factor (GDNF) after applying antidepressant treatment in patients with major 
      depressive disorder (MDD). We evaluated the serum BDNF and GDNF levels before and 
      after 12 weeks of antidepressant treatment in MDD outpatients. METHODS: Serum 
      BDNF and GDNF levels were measured in 23 female MDD outpatients at baseline and 
      after 12 weeks of treatment. The severity of depression was measured with the 
      Hamilton Depression Rating Scale-17 (HAMD-17). Remission of MDD to the treatment 
      was defined as a posttreatment HAMD-17 score of <7. RESULTS: Among MDD 
      patients, 19 (82.6%) subjects were in mild to moderate depression. The whole MDD 
      patients had significantly higher serum BDNF and GDNF levels at baseline than 
      those after 12 weeks of antidepressant treatment. The baseline serum BDNF and 
      GDNF levels did not significantly between the remission and nonremission groups. 
      The significant alteration in both BDNF and GDNF levels after antidepressant 
      treatment were observed in patients with remission. CONCLUSION: The present study 
      suggests that the baseline serum BDNF and GDNF levels are higher than the 
      posttreatment levels in some mild-to-moderate MDD outpatients and the significant 
      alteration in BDNF and GDNF level after treatment were observed in patients with 
      remission.
FAU - Park, Young-Min
AU  - Park YM
AD  - Department of Psychiatry, Ilsan Paik Hospital, Inje University College of 
      Medicine, Goyang, Republic of Korea.
FAU - Lee, Bun-Hee
AU  - Lee BH
AD  - Maum & Maum Psychiatric Clinic, Seoul, Republic of Korea.
LA  - eng
GR  - 2014R1A1A2A10059345/National Research Foundation of Korea/
GR  - Ministry of Education/
PT  - Journal Article
DEP - 20180628
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC6111227
OTO - NOTNLM
OT  - Glial cell line-derived neurotrophic factor
OT  - Major depression
OT  - Remission
OT  - Brain-derived neurotrophic factor
EDAT- 2018/06/28 06:00
MHDA- 2018/06/28 06:01
PMCR- 2018/08/01
CRDT- 2018/06/28 06:00
PHST- 2017/12/31 00:00 [received]
PHST- 2018/03/31 00:00 [accepted]
PHST- 2018/06/28 06:00 [pubmed]
PHST- 2018/06/28 06:01 [medline]
PHST- 2018/06/28 06:00 [entrez]
PHST- 2018/08/01 00:00 [pmc-release]
AID - pi.2018.03.31 [pii]
AID - pi-2018-03-31 [pii]
AID - 10.30773/pi.2018.03.31 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2018 Aug;15(8):818-823. doi: 10.30773/pi.2018.03.31. Epub 
      2018 Jun 28.