PMID- 29946859
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20240331
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 235
IP  - 9
DP  - 2018 Sep
TI  - An observational study on the sub-acute effects of mephedrone on mood, cognition, 
      sleep and physical problems in regular mephedrone users.
PG  - 2609-2618
LID - 10.1007/s00213-018-4953-1 [doi]
AB  - RATIONALE: Mephedrone (4-methylmethcathinone; 4-MMC) is a novel recreational drug 
      similar to methylenedioxymethamphetamine (MDMA) and amphetamine. Several adverse 
      effects have been reported, but little is known about its sub-acute effects. 
      OBJECTIVES: To study sub-acute effects of mephedrone over a period of 9 days. 
      METHODS: Recreational mephedrone users were recruited and followed over a time 
      period of 9 days. It was recorded whether participants consumed mephedrone or not 
      within the period of testing; those who did were compared to those who did not. 
      Forty-six regular mephedrone users (22 males, 24 females) participated, 21 
      participants voluntarily opted to consume mephedrone 1-3 days after baseline and 
      25 opted to abstain. Participants were assessed at baseline on a multitude of 
      measures and provided daily reports on cognition, sleep, mood, physical problems, 
      mephedrone cravings and substance use on each subsequent day of the study. The 
      study controlled for psychopathology, sleep, past and current substance use, 
      impulsivity and demographics. RESULTS: Those who consumed mephedrone reported 
      persistent negative mood, physical problems and fatigue, compared to those who 
      did not-after controlling for baseline group differences in sleep and subsequent 
      alcohol and cannabis use. CONCLUSIONS: The results provide the first prospective 
      evidence of the duration and extent of specific undesirable sub-acute effects of 
      mephedrone in regular recreational users and indicate sub-acute effects of 
      mephedrone on mood, fatigue and physical symptoms.
FAU - Homman, Lina
AU  - Homman L
AUID- ORCID: 0000-0002-5927-7050
AD  - Department of Psychology, University of Sussex, Brighton, BN1 9RH, UK. 
      lina.homman@liu.se.
AD  - Center for Social and Affective Neuroscience, Linkoping University, 581 83, 
      Linkoping, Sweden. lina.homman@liu.se.
FAU - Seglert, Jessica
AU  - Seglert J
AD  - Department of Psychology, University of Sussex, Brighton, BN1 9RH, UK.
FAU - Morgan, Michael J
AU  - Morgan MJ
AD  - Department of Psychology, University of Sussex, Brighton, BN1 9RH, UK.
AD  - Norwegian Center for Addiction Research, University of Oslo, 0315, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180626
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Illicit Drugs)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
SB  - IM
MH  - Adult
MH  - Affect/drug effects/physiology
MH  - Cognition/*drug effects/physiology
MH  - Drug Users/*psychology
MH  - Fatigue/*chemically induced/diagnosis/psychology
MH  - Female
MH  - Humans
MH  - Illicit Drugs/*adverse effects
MH  - Male
MH  - Methamphetamine/administration & dosage/adverse effects/*analogs & derivatives
MH  - Mood Disorders/*chemically induced/diagnosis/psychology
MH  - Prospective Studies
MH  - Sleep/drug effects/physiology
MH  - Substance-Related Disorders/psychology
PMC - PMC6132682
OTO - NOTNLM
OT  - Cathinone
OT  - Cognition
OT  - Mephedrone
OT  - Mood
OT  - Physical problems
OT  - Sleep
OT  - Sub-acute effects
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/06/28 06:00
MHDA- 2018/11/07 06:00
PMCR- 2018/06/26
CRDT- 2018/06/28 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/06/28 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2018/06/28 06:00 [entrez]
PHST- 2018/06/26 00:00 [pmc-release]
AID - 10.1007/s00213-018-4953-1 [pii]
AID - 4953 [pii]
AID - 10.1007/s00213-018-4953-1 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2018 Sep;235(9):2609-2618. doi: 
      10.1007/s00213-018-4953-1. Epub 2018 Jun 26.