PMID- 29947339
OWN - NLM
STAT- MEDLINE
DCOM- 20181018
LR  - 20211204
IS  - 1735-367X (Electronic)
IS  - 1735-1383 (Linking)
VI  - 15
IP  - 2
DP  - 2018 Jun
TI  - HLA Class I and Class II Genes Distribution of the Iranian Sistanis.
PG  - 97-111
AB  - BACKGROUND: The high polymorphism in the human leukocyte antigen (HLA) genes can 
      be used as an identity of individuals to compare with other populations. This 
      extreme polymorphism in the HLA system is accountable for the differences in 
      alleles and haplotypes among ethnic groups, populations, and the inhabitants of 
      many regions. OBJECTIVE: To define the frequency of HLA alleles and haplotypes 
      among the Sistanis, Sistani/Zaboli population in Iran. METHODS: In this study, 
      genotyping of class I (A, B, C) and class II HLA (DRB1, DQA1, DQB1) loci were 
      determined in 90 unrelated Iraninan Sistani people and the results were compared 
      with 474,892 HLA chromosomes from a diverse worldwide population. RESULTS: The 
      highest frequently observed alleles in this study were A*02:01, B*35:01, C*12:03, 
      C*06:02, DRB1*11, DQA1*05:05, and DQB1*03:01. Furthermore, the most frequent 
      3-locus haplotypes were A*02:01-B*50:01*C*06:02, DRB1*11-DQB1*03:01-DQA1*05:05, 
      and A*02:01-B*50:01-DRB1*07. The most occurring 4-locus haplotypes were 
      A*02:01-B*50:01-C*06:02-DRB1*07 and A*02:01-B*50:01-DRB1*07-DQB1*02:01. 
      A*02:01-B*50:01-C*06:02-DRB1*07-DQB1*02:01 and 
      A*02:01-B*50:01-C*06:02-DRB1*07-DQB1*02:01-DQA1*02:01 were determined to be the 
      predominant 5- and 6-locus haplotypes, respectively. The heat maps and multiple 
      correspondence analyses based on the frequency of HLA alleles showed that 
      Sistanis share a common genetic inheritance with other Iranian ethnic groups such 
      as the people from Yazd and Fars except some differences with Baluchis, Iranian 
      Jews, Lurs of Kohgiluyeh/Buyerahmad, and Arabs of Fars, which may arise from the 
      admixture of these groups or with foreign subgroups over centuries, and also a 
      close relatedness with some European populations. CONCLUSION: These data could be 
      useful for finding better donor matches for organ transplantation among Sistanis 
      or other related Iranian ethnic groups, epidemiological studies of HLA-associated 
      diseases, handling HLA genomics and mapping the migration pattern of different 
      ethnic group.
FAU - Aminikhah, Mahdi
AU  - Aminikhah M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Yekaninejad, Mir-Saeed
AU  - Yekaninejad MS
FAU - Nicknam, Mohammad Hosein
AU  - Nicknam MH
FAU - Khosravi, Farideh
AU  - Khosravi F
FAU - Naroeinejad, Mehrnaz
AU  - Naroeinejad M
FAU - Ansaripour, Bita
AU  - Ansaripour B
FAU - Moradi, Batol
AU  - Moradi B
FAU - Nikbin, Behrouz
AU  - Nikbin B
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Immunol
JT  - Iranian journal of immunology : IJI
JID - 101282932
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Cluster Analysis
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - *Genetics, Population
MH  - Geography
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Iran
MH  - Linkage Disequilibrium
MH  - Polymorphism, Genetic
EDAT- 2018/06/28 06:00
MHDA- 2018/10/20 06:00
CRDT- 2018/06/28 06:00
PHST- 2018/06/28 06:00 [entrez]
PHST- 2018/06/28 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
AID - 03 [pii]
PST - ppublish
SO  - Iran J Immunol. 2018 Jun;15(2):97-111.