PMID- 29948606 OWN - NLM STAT- MEDLINE DCOM- 20181004 LR - 20181114 IS - 1573-2649 (Electronic) IS - 0962-9343 (Linking) VI - 27 IP - 9 DP - 2018 Sep TI - Evaluation of the internal and external responsiveness of Short Form-12 Health Survey version 2 (SF-12v2) in patients with type 2 diabetes mellitus. PG - 2459-2469 LID - 10.1007/s11136-018-1908-2 [doi] AB - PURPOSE: The evidence on the responsiveness of the Short Form-12 Health Survey version 2 (SF-12v2) in patients with type 2 diabetes mellitus (T2DM) is limited. The aim of this study was to examine both the internal and external responsiveness of the SF-12 measures in Chinese patients with T2DM. METHODS: A prospective longitudinal observational study was conducted on 1443 T2DM patients managed in public primary care clinics between 2012 and 2013. These patients were surveyed at baseline and at 12 months using SF-12v2. The internal responsiveness was evaluated by linear mixed effect models. Meanwhile, the external responsiveness was tested by multiple linear regression models and receiver operating characteristic (ROC) curve analysis. RESULTS: The internal responsiveness of the SF-12v2 to detect negative change was satisfactory among T2DM patients in worsened group, but only the general health domain of SF-12v2 could detect positive change among T2DM patients with improved group. For external responsiveness, the SF-12v2 detected a significant difference-in-difference between patients with worsened and stable/improved group, but not between patients with stable and improved group. The areas under the ROC curve for all domains and summary scales of the SF-12v2 were not statistically different from 0.7. CONCLUSION: This study showed that the responsiveness of SF-12v2 might not achieve the standard. Despite the wide use of the SF-12v2, we would like to urge that both clinicians and researchers should use it with caution in longitudinal study. FAU - Wan, Eric Yuk Fai AU - Wan EYF AUID- ORCID: 0000-0002-6275-1147 AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. yfwan@hku.hk. FAU - Choi, Edmond Pui Hang AU - Choi EPH AD - School of Nursing, The University of Hong Kong, 4/F William MW Mong Block, 21 Sassoon Road, Pokfulam, Hong Kong. FAU - Yu, Esther Yee Tak AU - Yu EYT AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. FAU - Chin, Weng Yee AU - Chin WY AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. FAU - Fung, Colman Siu Cheung AU - Fung CSC AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. FAU - Chan, Anca Ka Chun AU - Chan AKC AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. FAU - Lam, Cindy Lo Kuen AU - Lam CLK AD - Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong. LA - eng GR - EPC-HKU-2/Food and Health Bureau/ PT - Journal Article DEP - 20180613 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Aged MH - Diabetes Mellitus, Type 2/*diagnosis/pathology MH - Female MH - Health Surveys/*methods MH - Humans MH - Longitudinal Studies MH - Male MH - Prospective Studies MH - Quality of Life/*psychology MH - Reproducibility of Results OTO - NOTNLM OT - Health-related quality of life (HRQOL) OT - Primary care OT - Responsiveness OT - Short Form-12 Health Survey version 2 (SF-12v2) OT - Type 2 diabetes mellitus (T2DM) EDAT- 2018/06/28 06:00 MHDA- 2018/10/05 06:00 CRDT- 2018/06/28 06:00 PHST- 2018/06/05 00:00 [accepted] PHST- 2018/06/28 06:00 [pubmed] PHST- 2018/10/05 06:00 [medline] PHST- 2018/06/28 06:00 [entrez] AID - 10.1007/s11136-018-1908-2 [pii] AID - 10.1007/s11136-018-1908-2 [doi] PST - ppublish SO - Qual Life Res. 2018 Sep;27(9):2459-2469. doi: 10.1007/s11136-018-1908-2. Epub 2018 Jun 13.