PMID- 29949836
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 10
IP  - 4
DP  - 2018 Jul
TI  - Association of Genetic Polymorphisms with Atopic Dermatitis, Clinical Severity 
      and Total IgE: A Replication and Extended Study.
PG  - 397-405
LID - 10.4168/aair.2018.10.4.397 [doi]
AB  - PURPOSE: Atopic dermatitis (AD) is a common and chronic inflammatory skin disease 
      affecting up to 20% of children and 3% of adults worldwide. Although previous 
      reports including genome-wide association study (GWAS) approaches have identified 
      several risk factors that appear to be associated with AD development, 
      replication studies are lacking. In our current study, we replicated the 
      associations between candidate susceptibility loci and AD. METHODS: A total of 
      885 Korean subjects (425 AD patients and 460 unaffected controls) were genotyped 
      for 17 single nucleotide polymorphisms (SNPs) from previous GWASs and 
      meta-analyses of AD and from immune-related genes. RESULTS: Several SNPs showed 
      significant associations with AD in the case-control analysis (minimum P=0.005 at 
      rs17389644), suggesting that these polymorphisms may be related to this disease. 
      In addition, several SNPs showed significant signals (minimum P=0.004 at 
      rs6473227) in severe AD compared to unaffected controls. In additional linear 
      regression analysis, a few genotypes appeared to have potential effects on the 
      SCORing AD (SCORAD) values (minimum P=0.003 at rs13361382 on TMEM232) and 
      immunoglobulin E (IgE) levels (minimum P<0.0001 at rs4713555 near HLA-DRB1 and 
      HLA-DQA1) in AD patients. CONCLUSIONS: Our replication and extended study provide 
      additional supporting information on the genetic associations (especially, 
      variants in TMEM232 and nearby to IL21 and HLA-DRB1/HLA-DQA1) related to AD, its 
      clinical severity and IgE involvement.
CI  - Copyright (c) 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Kim, Jeong Hyun
AU  - Kim JH
AUID- ORCID: 0000-0003-4879-0075
AD  - Department of Medicine, University of Ulsan Collage of Medicine, Seoul, Korea.
FAU - Lee, So Yeon
AU  - Lee SY
AUID- ORCID: 0000-0002-2499-0702
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan Collage of Medicine, Seoul, 
      Korea.
FAU - Kang, Mi Jin
AU  - Kang MJ
AUID- ORCID: 0000-0001-8510-3268
AD  - Asan Institute for Life Sciences, University of Ulsan Collage of Medicine, Seoul, 
      Korea.
FAU - Yoon, Jisun
AU  - Yoon J
AUID- ORCID: 0000-0002-4904-9118
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan Collage of Medicine, Seoul, 
      Korea.
FAU - Jung, Sungsu
AU  - Jung S
AUID- ORCID: 0000-0002-0559-4982
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan Collage of Medicine, Seoul, 
      Korea.
FAU - Cho, Hyun Ju
AU  - Cho HJ
AUID- ORCID: 0000-0003-4282-4000
AD  - Department of Pediatrics, Mediplex Sejong Hospital, Incheon, Korea.
FAU - Kim, Hyo Bin
AU  - Kim HB
AUID- ORCID: 0000-0002-1928-722X
AD  - Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
FAU - Hong, Soo Jong
AU  - Hong SJ
AUID- ORCID: 0000-0003-1409-2113
AD  - Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health 
      Center, Asan Medical Center, University of Ulsan Collage of Medicine, Seoul, 
      Korea. sjhong@amc.seoul.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6021591
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - single nucleotide polymorphism, severity
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2018/06/28 06:00
MHDA- 2018/06/28 06:01
PMCR- 2018/07/01
CRDT- 2018/06/28 06:00
PHST- 2017/12/22 00:00 [received]
PHST- 2018/04/11 00:00 [revised]
PHST- 2018/04/13 00:00 [accepted]
PHST- 2018/06/28 06:00 [entrez]
PHST- 2018/06/28 06:00 [pubmed]
PHST- 2018/06/28 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 10.397 [pii]
AID - 10.4168/aair.2018.10.4.397 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2018 Jul;10(4):397-405. doi: 
      10.4168/aair.2018.10.4.397.