PMID- 29951384
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 1016-1430 (Print)
IS  - 2251-6840 (Electronic)
IS  - 1016-1430 (Linking)
VI  - 31
DP  - 2017
TI  - The Relationship between insulin variable number of tandem repeats (INS-VNTR) -23 
      A/T and cytotoxic Tlymphocyte associated protein-4 (CTLA-4) +49 A/G polymorphisms 
      with islet autoantibodies in persons with diabetes.
PG  - 83
LID - 10.18869/mjiri.31.83 [doi]
AB  - Background: Both genetic and environmental factors are important in pathogenesis 
      of diabetes. Non HLA (Human Leukocyte Antigen) genes such as INS-VNTR and CTLA-4 
      in addition of HLA genes have influence on genetic susceptibility for diabetes 
      mellitus. In this study the association of +49 A/G CTLA-4 and -23 A/T INS-VNTR 
      polymorphisms with diabetes and their association with islet autoantibodies were 
      investigated. Methods: Thirty four autoantibody positive adult persons with 
      diabetes mellitus and 39 persons with Type 1diabetes mellitus (T1DM), 40 
      autoantibody negative Type 2 diabetes mellitus (T2DM) patients and 40 healthy 
      controls were studied using Polymerase Chain Reaction-Restriction Fragment Length 
      Polymorphism (PCR-RFLP) technique. Results: The frequencies of -23 A/T INS-VNTR 
      genotypes were not significantly different among study groups. It was shown that 
      the distribution of the +49A/G CTLA-4 allele and genotype frequencies did not 
      differ between T1DM patients, autoantibody positive adult patients and controls. 
      With increasing CTLA-4 G allele and GG/AG genotypes, the frequency of Glutamic 
      Acid Decarboxylase Autoantibody (GADA), Islet Cell Autoantibody (ICA) and Islet 
      Antigen 2 Antibody (IA2A) positive patients were increased. Conclusion: Our 
      results suggest that susceptibility allele A of -23A/T INS-VNTR does not have any 
      role in the pathogenesis of diabetes in our patients and susceptibility allele G 
      of +49 A/G CTLA-4 if not, has a small role in pathogenesis of diabetes in T1DM 
      and autoantibody positive adult patients and in spite of significant increase in 
      autoantibody negative T2DM group it does not have any role in disease 
      pathogenesis.
FAU - Khoshroo, Mohammad
AU  - Khoshroo M
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Khamseh, Mohammad Ebrahim
AU  - Khamseh ME
AD  - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Amir Zargar, Ali Akbar
AU  - Amir Zargar AA
AD  - Molecular Immunology Research Center, Tehran University of Medical Science, 
      Tehran, Iran.
FAU - Malek, Mojtaba
AU  - Malek M
AD  - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Falak, Reza
AU  - Falak R
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Shekarabi, Mehdi
AU  - Shekarabi M
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran & Immunology Research Center, Iran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20171212
PL  - Iran
TA  - Med J Islam Repub Iran
JT  - Medical journal of the Islamic Republic of Iran
JID - 8910777
PMC - PMC6014810
OTO - NOTNLM
OT  - Autoantibodies
OT  - CTLA-4
OT  - Diabetes Mellitus
OT  - INS-VNTR
OT  - Polymorphism
EDAT- 2018/06/29 06:00
MHDA- 2018/06/29 06:01
PMCR- 2017/12/12
CRDT- 2018/06/29 06:00
PHST- 2016/02/05 00:00 [received]
PHST- 2018/06/29 06:00 [entrez]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2018/06/29 06:01 [medline]
PHST- 2017/12/12 00:00 [pmc-release]
AID - 10.18869/mjiri.31.83 [doi]
PST - epublish
SO  - Med J Islam Repub Iran. 2017 Dec 12;31:83. doi: 10.18869/mjiri.31.83. eCollection 
      2017.