PMID- 29951415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 1016-1430 (Print)
IS  - 2251-6840 (Electronic)
IS  - 1016-1430 (Linking)
VI  - 31
DP  - 2017
TI  - Comparison of hematological parameters, iron levels, and oxidative stress in 
      women with and without breast cancer: A case- control study.
PG  - 114
LID - 10.14196/mjiri.31.114 [doi]
AB  - Background: Iron is one of the nutrients that has recently received considerable 
      attention because of its dual role in the incidence of breast cancer. The present 
      study aimed at comparing hematological parameters, iron levels, and oxidative 
      stress in women with and without breast cancer. Methods: The participants in this 
      case-control study were 55 women, of whom 26 were new cases of breast cancer 
      (confirmed by biopsy) as the case, and 29 without cancer (confirmed by 
      mammography) as the control group. All participants underwent blood testing for 
      complete blood count (CBC (free iron, ferritin, total iron binding capacity) TIBC 
      (2, 2-diphenyl-1-picrylhydrazyl (DPPH), and Malondialdehyde (MDA). Results: The 
      mean+/-SD age of the participants was 44.25+/-9.82 years, and there was no 
      significant difference between groups. Also, no statistically significant 
      difference was found between the 2 groups in variables, except the mean 
      corpuscular volume of red cells (MCV), mean corpuscular hemoglobin concentration 
      (MCHC), and mean cell hemoglobin (MCH). The use of iron supplements was 
      significantly higher in the control than in the case group (p= 0. 01), with an 
      odds ratio of 0.19% (95% CI: 0.45-0.7). The mean serum DPPH was significantly 
      higher in the control than in the case group (p= 0. 006), but comparison of serum 
      MDA showed no significant difference between the 2 groups. Conclusion: Iron 
      deficiency anemia was greater in patients with breast cancer than in those 
      without it. Moreover, iron supplementation appears to have a protective effect 
      against breast cancer incidence. In addition, serum DPPH, as a total antioxidant 
      index, was significantly higher in the control group.
FAU - Rajizadeh, Afsaneh
AU  - Rajizadeh A
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Mozaffari-Khosravi, Hassan
AU  - Mozaffari-Khosravi H
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Zavar-Reza, Javad
AU  - Zavar-Reza J
AD  - Department of Biochemistry, Faculty of Medicine, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Shiryazdi, Seyyed Mostafa
AU  - Shiryazdi SM
AD  - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
LA  - eng
PT  - Journal Article
DEP - 20171220
PL  - Iran
TA  - Med J Islam Repub Iran
JT  - Medical journal of the Islamic Republic of Iran
JID - 8910777
PMC - PMC6014764
OTO - NOTNLM
OT  - Breast cancer
OT  - Iron status
OT  - Oxidative stress
OT  - Premenopausal
EDAT- 2018/06/29 06:00
MHDA- 2018/06/29 06:01
PMCR- 2017/12/20
CRDT- 2018/06/29 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2018/06/29 06:00 [entrez]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2018/06/29 06:01 [medline]
PHST- 2017/12/20 00:00 [pmc-release]
AID - 10.14196/mjiri.31.114 [doi]
PST - epublish
SO  - Med J Islam Repub Iran. 2017 Dec 20;31:114. doi: 10.14196/mjiri.31.114. 
      eCollection 2017.