PMID- 2995259
OWN - NLM
STAT- MEDLINE
DCOM- 19851112
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 36
IP  - 4
DP  - 1985 Oct 15
TI  - Selective cytotoxicity of AIDS virus infection towards HTLV-I-transformed cell 
      lines.
PG  - 445-51
AB  - Previously, we reported that cells of the human T-cell lymphotropic virus type I 
      (HTLV-I)-transformed lines MT-2 and MT-4 were extensively killed by infection 
      with AIDS retrovirus HTLV-III. We have investigated this phenomenon more 
      systematically using light and electron microscopy as well as immunofluorescence. 
      The cell lines used in the present studies included 14 of those carrying not only 
      human HTLV-I but also related simian agents and 6 HTLV-I-negative T- and B-cell 
      lines. The results showed that the cytocidal effects occurred in the 
      HTLV-I-transformed cell lines exclusively and were not present in further 
      subcultures. In these cell lines the cytotoxic response was closely correlated 
      with the induction of HTLV-III antigens after virus infection. However, cells of 
      6 HTLV-I-free lines were not killed to a marked extent by HTLV-III and were 
      passaged as continuous producers of AIDS virus. Only 2 cell lines were resistant 
      to the cytocidal effect of HTLV-III among 14 HTLV-I carrying cell lines. They 
      were also resistant to the replication of infected HTLV-III. This AIDS 
      virus-specific cytotoxic effect observed in HTLV-I-transformed cell lines did not 
      appear to be associated with gene expression of the gag and pXs region of HTLV-I 
      genomes. This result may indicate that HTLV-III specifically interferes with some 
      steps of HTLV-I transformation.
FAU - Koyanagi, Y
AU  - Koyanagi Y
FAU - Harada, S
AU  - Harada S
FAU - Takahashi, M
AU  - Takahashi M
FAU - Uchino, F
AU  - Uchino F
FAU - Yamamoto, N
AU  - Yamamoto N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*microbiology
MH  - Cell Division
MH  - Cell Line
MH  - Cell Survival
MH  - *Cell Transformation, Viral
MH  - Cytopathogenic Effect, Viral
MH  - Cytoplasm/ultrastructure
MH  - *Deltaretrovirus/growth & development
MH  - Gene Expression Regulation
MH  - Humans
MH  - Inclusion Bodies, Viral/ultrastructure
MH  - Microscopy, Electron
MH  - Virus Replication
EDAT- 1985/10/15 00:00
MHDA- 1985/10/15 00:01
CRDT- 1985/10/15 00:00
PHST- 1985/10/15 00:00 [pubmed]
PHST- 1985/10/15 00:01 [medline]
PHST- 1985/10/15 00:00 [entrez]
AID - 10.1002/ijc.2910360406 [doi]
PST - ppublish
SO  - Int J Cancer. 1985 Oct 15;36(4):445-51. doi: 10.1002/ijc.2910360406.