PMID- 29952956
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 26
DP  - 2018 Jun
TI  - Comprehensive analysis of common safety profiles and their predictive factors in 
      520 records of liver cancer patients treated by drug-eluting beads transarterial 
      chemoembolization.
PG  - e11131
LID - 10.1097/MD.0000000000011131 [doi]
LID - e11131
AB  - This study aimed to investigate the difference of common adverse events (AEs) 
      between patients experienced first drug-eluting beads transarterial 
      chemoembolization (DEB-TACE; FD) and second or higher DEB-TACE (SHD), and the 
      factors influencing AEs.Five hundred twenty DEB-TACE records were retrospectively 
      reviewed in this cohort study, among which 284 and 236 records were in FD and SHD 
      groups, respectively. The incidence and/or severity of pain, fever, vomiting, and 
      increased blood pressure (BP) were collected.Pain numerical rating scale (NRS) 
      score, pain severity, body temperature, fever severity, and fever lasting days 
      were higher in FD group than in SHD group, while no difference of vomiting and 
      increased BP between 2 groups were disclosed. Age >/=65 years was associated with 
      decreased high fever and less possibility of vomiting in FD group, and lower pain 
      and fever severity in SHD group; Male decreased the possibility of vomiting in 
      both the groups, and reduced increased BP incidence in SHD group; diabetes 
      history correlated with decreased pain degree and less fever in FD group.In 
      conclusion, SHD was better tolerated compared with FD in liver cancer patients, 
      and older age as well as male were correlated with less occurrence or severity of 
      common AEs in DEB-TACE operation.
FAU - Sun, Junhui
AU  - Sun J
AD  - Hepatobiliary and Pancreatic Interventional Treatment Center, Division of 
      Hepatobiliary and Pancreatic Surgery, Hepatobiliary and Pancreatic Clinical 
      Medical Center, The First Affiliated Hospital, School of Medicine, Zhejiang 
      University Key Laboratory of Combined Multi-organ Transplantation, Ministry of 
      Public Health Key Laboratory of Precision Diagnosis and Treatment for 
      Hepatobiliary and Pancreatic Tumor of Zhejiang Province Medical Engineering and 
      Information Innovation Center, Zhejiang University Collaborative Innovation 
      Center for Diagnosis Treatment of Infectious Diseases, Zhejiang University, 
      Hangzhou, China.
FAU - Zhou, Guanhui
AU  - Zhou G
FAU - Zhang, Yuelin
AU  - Zhang Y
FAU - Zhou, Tanyang
AU  - Zhou T
FAU - Nie, Chunhui
AU  - Nie C
FAU - Zhu, Tongyin
AU  - Zhu T
FAU - Chen, Shengqun
AU  - Chen S
FAU - Wang, Baoquan
AU  - Wang B
FAU - Yu, Ziniu
AU  - Yu Z
FAU - Wang, Hongliang
AU  - Wang H
FAU - Chen, Xinhua
AU  - Chen X
FAU - Hong, Liangjie
AU  - Hong L
FAU - Chen, Liming
AU  - Chen L
FAU - Wang, Weilin
AU  - Wang W
FAU - Zheng, Shusen
AU  - Zheng S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemoembolization, Therapeutic/*adverse effects/instrumentation/trends
MH  - Drug-Eluting Stents/*adverse effects/trends
MH  - Female
MH  - Fever/epidemiology
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Incidence
MH  - Liver/pathology
MH  - Liver Neoplasms/*therapy
MH  - Male
MH  - Middle Aged
MH  - Pain/epidemiology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Vomiting/epidemiology
PMC - PMC6039676
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2018/06/29 06:00
MHDA- 2018/07/10 06:00
PMCR- 2018/06/29
CRDT- 2018/06/29 06:00
PHST- 2018/06/29 06:00 [entrez]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2018/06/29 00:00 [pmc-release]
AID - 00005792-201806290-00019 [pii]
AID - MD-D-17-07984 [pii]
AID - 10.1097/MD.0000000000011131 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jun;97(26):e11131. doi: 10.1097/MD.0000000000011131.