PMID- 29953078
OWN - NLM
STAT- MEDLINE
DCOM- 20190814
LR  - 20190814
IS  - 0042-465X (Print)
IS  - 0042-465X (Linking)
VI  - 134
IP  - 3
DP  - 2018
TI  - [Pattern visual evoked potentials and their relation to the peripapillary and 
      retrobulbar blood flow in glaucoma].
PG  - 19-27
LID - 10.17116/oftalma2018134319 [doi]
AB  - PURPOSE: To examine the relationship between the development of bioelectric 
      response of retinal cell elements to pattern stimulus and the ocular blood flow. 
      MATERIAL AND METHODS: Electrophysiological studies, including pattern-reversal 
      visual evoked potentials (VEP) with large 1 degree (1 degrees ) and small 0.25 degrees  checks, 
      Color Doppler imaging (CDI) of the retrobulbar vessels, and OCT Angiography in 
      the area of the optic disc and peripapillary retina were performed in 48 patients 
      with initial primary open-angle glaucoma (POAG), 47 patients with advanced POAG, 
      and 42 control subjects. Authors also studied the correlations between VEP values 
      and the parameters used in CDI and OCT-A examination. RESULTS: The most 
      noticeable differences between the study groups were the amplitudes of P100 
      pattern VEP values for small and large patterns and the OCT-A parameters: 
      Whole-image Disc Vessel Density (widVD), Peripapillary Vessel Density (pVD), 
      Peripapillary Vessel Density Inferior Temporalis (pVD IT). In initial glaucoma, a 
      strong correlation was observed between the amplitude of P100 pattern VEP 1 degrees  and 
      pVD IT (r=0.75; p<0.0001); the blood flow rates in ophthalmic artery, central 
      retinal artery, central retinal vein and short posterior ciliary arteries were 
      below normal, while the blood flow in these vessels had statistically reliable 
      correlation with the amplitude of P100 pattern VEP (p<0.05). No correlation was 
      found in patients with advanced stages of glaucoma. CONCLUSION: Pattern VEP is an 
      informative method of glaucoma diagnostics which accuracy can be enhanced by 
      combining it with OCT-A blood flow examination.
FAU - Kurysheva, N I
AU  - Kurysheva NI
AD  - Consultative-diagnostic Department of Ophthalmology Center of the Federal Medical 
      and Biological Agency, Burnasyan Federal Medical Biophysical Center of FMBA, 
      Department of Ophthalmology at Institute of Advanced Training of FMBA, 15 Gamalei 
      St., Moscow, Russian Federation, 123098.
FAU - Maslova, E V
AU  - Maslova EV
AD  - Consultative-diagnostic Department of Ophthalmology Center of the Federal Medical 
      and Biological Agency, Burnasyan Federal Medical Biophysical Center of FMBA, 
      Department of Ophthalmology at Institute of Advanced Training of FMBA, 15 Gamalei 
      St., Moscow, Russian Federation, 123098.
FAU - Trubilina, A V
AU  - Trubilina AV
AD  - Consultative-diagnostic Department of Ophthalmology Center of the Federal Medical 
      and Biological Agency, Burnasyan Federal Medical Biophysical Center of FMBA, 
      Department of Ophthalmology at Institute of Advanced Training of FMBA, 15 Gamalei 
      St., Moscow, Russian Federation, 123098.
FAU - Fomin, A V
AU  - Fomin AV
AD  - Research Institute of Eye Diseases, 11 A, B Rossolimo St., Moscow, Russian 
      Federation, 119021.
FAU - Lagutin, M B
AU  - Lagutin MB
AD  - Lomonosov Moscow State University, Faculty of Mechanics and Mathematics, 
      Department of Mathematical Statistics and Random Processes, GSP-1, Leninskie 
      Gory, Moscow, Russian Federation, 119991.
LA  - rus
PT  - Journal Article
TT  - Patternzritel'nye vyzvannye potentsialy i ikh sviaz' s peripapilliarnym i 
      retrobul'barnym krovotokom pri glaukome.
PL  - Russia (Federation)
TA  - Vestn Oftalmol
JT  - Vestnik oftalmologii
JID - 0415216
MH  - Blood Flow Velocity
MH  - Ciliary Arteries
MH  - *Evoked Potentials, Visual
MH  - *Glaucoma
MH  - *Glaucoma, Open-Angle/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - *Optic Disk
OTO - NOTNLM
OT  - OCT angiography
OT  - color Doppler imaging of retrobulbar vessels
OT  - ocular blood flow
OT  - primary open-angle glaucoma diagnostics
OT  - visual evoked potentials
EDAT- 2018/06/29 06:00
MHDA- 2019/08/15 06:00
CRDT- 2018/06/29 06:00
PHST- 2018/06/29 06:00 [entrez]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2019/08/15 06:00 [medline]
AID - 10.17116/oftalma2018134319 [doi]
PST - ppublish
SO  - Vestn Oftalmol. 2018;134(3):19-27. doi: 10.17116/oftalma2018134319.