PMID- 29953672
OWN - NLM
STAT- MEDLINE
DCOM- 20191010
LR  - 20211204
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 119
IP  - 11
DP  - 2018 Nov
TI  - Silencing forkhead box M1 promotes apoptosis and autophagy through 
      SIRT7/mTOR/IGF2 pathway in gastric cancer cells.
PG  - 9090-9098
LID - 10.1002/jcb.27168 [doi]
AB  - Forkhead box M1 (FOXM1) was initially identified as an oncogenic transcription 
      factor, and multiple lines of evidence have demonstrated that FOXM1 is abundantly 
      expressed and plays an irreplaceable role in several types of human cancers. 
      Also, evidence has shown the association of FOXM1 with gastric carcinoma 
      metastasis and patients prognosis; however, the potential role and molecular 
      mechanism of FOXM1 in gastric cancer cell apoptosis are still obscure. The 
      current study indicates that FOXM1 is highly expressed in a variety of gastric 
      carcinoma cell lines, such as BGC823, MGC803, AGS, and SGC-7901, compared with 
      the normal gastric mucosal epithelial cell lines CES-1. FOXM1 silence markedly 
      inhibits AGS and SGC-7901 cell survival and proliferation, increases their 
      apoptosis, and modulates apoptosis-related protein expression, including reduced 
      Bcl-2 level and increased Bax and caspase-3 levels. Further study showed that 
      FOXM1 depletion induced cell autophagy through increasing the level of beclin-1 
      and decreasing the P62 expression. We next corroborated that FOXM1 silence 
      abolished the expression of Sirtuin 7 (SIRT7) and increased the level of 
      insulin-like growth factor 2 (IGF2) and mammalian target of rapamycin (mTOR). 
      Finally, our data documented that the SIRT7/mTOR/IGF2 pathway was involved in the 
      function of FOXM1 in AGS cell growth and apoptosis. In conclusion, these results 
      confirmed that FOXM1 is involved in gastric carcinoma progression via the 
      SIRT7/mTOR/IGF2 pathway.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Yu, Wei
AU  - Yu W
AD  - Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun, China.
FAU - Cui, Xiaofeng
AU  - Cui X
AD  - Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun, China.
FAU - Wan, Zhongyi
AU  - Wan Z
AD  - Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun, China.
FAU - Yu, Yanhui
AU  - Yu Y
AD  - Clinical Lab, The Second Hospital of Jilin University, Changchun, China.
FAU - Liu, Xiumin
AU  - Liu X
AD  - Clinical Lab, The Second Hospital of Jilin University, Changchun, China.
FAU - Jin, Lifang
AU  - Jin L
AUID- ORCID: 0000-0002-5127-5915
AD  - Department of Hematology and Oncology, The Second Hospital of Jilin University, 
      Changchun, China.
LA  - eng
PT  - Journal Article
DEP - 20180628
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (IGF2 protein, human)
RN  - 0 (SIRT7 protein, human)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.5.1.- (Sirtuins)
SB  - IM
MH  - Apoptosis/genetics/physiology
MH  - Autophagy/genetics/physiology
MH  - Caspase 3/genetics/metabolism
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Cell Survival/genetics/physiology
MH  - Forkhead Box Protein M1/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic/genetics/physiology
MH  - Humans
MH  - Insulin-Like Growth Factor II/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sirtuins/genetics/*metabolism
MH  - Stomach Neoplasms/genetics/*metabolism
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
OTO - NOTNLM
OT  - IGF2
OT  - SIRT7
OT  - forkhead box M1 (FOXM1)
OT  - gastric cancer (GC)
OT  - mTOR
EDAT- 2018/06/29 06:00
MHDA- 2019/10/11 06:00
CRDT- 2018/06/29 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/05/18 00:00 [accepted]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2018/06/29 06:00 [entrez]
AID - 10.1002/jcb.27168 [doi]
PST - ppublish
SO  - J Cell Biochem. 2018 Nov;119(11):9090-9098. doi: 10.1002/jcb.27168. Epub 2018 Jun 
      28.