PMID- 29953729
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20190628
IS  - 1749-4486 (Electronic)
IS  - 1749-4478 (Linking)
VI  - 43
IP  - 5
DP  - 2018 Oct
TI  - Minimal clinically important difference for the 22-item Sinonasal Outcome Test in 
      medically managed patients with chronic rhinosinusitis.
PG  - 1328-1334
LID - 10.1111/coa.13177 [doi]
AB  - OBJECTIVE: To determine the minimal clinically important difference (MCID) of the 
      22-item Sinonasal Outcome Test (SNOT-22) in individuals undergoing medical 
      management for their chronic rhinosinusitis (CRS). DESIGN: Prospective 
      observational study. SETTING: Academic, tertiary care centre. PARTICIPANTS: A 
      total of 247 adults undergoing medical management for CRS. MAIN OUTCOME MEASURE: 
      At enrolment, participants completed a SNOT-22. At a subsequent follow-up visit, 
      2-12 months after enrolment, participants also completed a SNOT-22. At follow-up, 
      participants also rated the change in their sinus symptoms and general health as 
      "Much worse," "A little worse," "About the same," "A little better" or "Much 
      better" compared with enrolment; these two questions were used as sinus symptom 
      and general health anchor questions, respectively. The SNOT-22 MCID was 
      calculated using distribution-based, anchor-based and receiver operating 
      characteristic (ROC) curve-based methods. RESULTS: Using the distribution-based 
      method, the SNOT-22 MCID was 11.6. Using the sinus symptom anchor question, the 
      SNOT-22 MCID was 10.5; applying the ROC method to the sinus symptom anchor 
      yielded an MCID of 12.5. In comparison, using the general health anchor question, 
      the SNOT-22 MCID was 8.3; applying the ROC method to the sinus symptom anchor 
      yielded an MCID of 17.5. In all cases, the calculated MCID had a sensitivity of 
      approximately 50-60% and specificity of approximately 80-90%. CONCLUSIONS: Based 
      on our results, we propose a SNOT-22 MCID of 12 in medically managed patients 
      with CRS. The MCID, while specific, was not sensitive for identifying patients 
      with CRS experiencing a noticeable improvement in sinus symptoms or general 
      health.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Phillips, Katie M
AU  - Phillips KM
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
AD  - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, 
      Massachusetts.
FAU - Hoehle, Lloyd P
AU  - Hoehle LP
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
AD  - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, 
      Massachusetts.
FAU - Caradonna, David S
AU  - Caradonna DS
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
AD  - Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts.
FAU - Gray, Stacey T
AU  - Gray ST
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
AD  - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, 
      Massachusetts.
FAU - Sedaghat, Ahmad R
AU  - Sedaghat AR
AUID- ORCID: 0000-0001-6331-2325
AD  - Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts.
AD  - Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, 
      Massachusetts.
AD  - Division of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts.
AD  - Department of Otolaryngology and Communications Enhancement, Boston Children's 
      Hospital, Boston, Massachusetts.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180726
PL  - England
TA  - Clin Otolaryngol
JT  - Clinical otolaryngology : official journal of ENT-UK ; official journal of 
      Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
JID - 101247023
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - ROC Curve
MH  - Rhinitis/*therapy
MH  - Sinusitis/*therapy
EDAT- 2018/06/29 06:00
MHDA- 2019/06/30 06:00
CRDT- 2018/06/29 06:00
PHST- 2018/01/01 00:00 [received]
PHST- 2018/06/22 00:00 [accepted]
PHST- 2018/06/29 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2018/06/29 06:00 [entrez]
AID - 10.1111/coa.13177 [doi]
PST - ppublish
SO  - Clin Otolaryngol. 2018 Oct;43(5):1328-1334. doi: 10.1111/coa.13177. Epub 2018 Jul 
      26.