PMID- 29955747
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 9
IP  - 7
DP  - 2018 Jul 17
TI  - Increased intake of vitamin B(12), folate, and omega-3 fatty acids to improve 
      cognitive performance in offspring born to rats with induced hypertension during 
      pregnancy.
PG  - 3872-3883
LID - 10.1039/c8fo00467f [doi]
AB  - Vitamin B12, folic acid, and docosahexaenoic acid levels are reported to be 
      altered in women with preeclampsia. This study examined the effect of the above 
      nutrients on brain neurotrophins and on the cognitive performance in adult 
      offspring in a pregnancy-induced hypertension rat model. Pregnant dams were 
      assigned to control, PIH-induced, and PIH-induced supplemented with vitamin B12, 
      folate, omega-3 fatty acids, and the combined supplementation of vitamin B12, 
      folate, and omega-3 fatty acids groups. In the PIH group, brain-derived 
      neurotrophic factor levels (BDNF) were lower in the offspring at birth, while the 
      adult offspring showed lower levels of docosahexaenoic acid (DHA) in the 
      hippocampus and BDNF (p < 0.05 for both) in the cortex as compared to in the 
      control group. They also demonstrated higher (p < 0.05) escape latency in the 
      Morris water maze test and performed a greater (p < 0.01 for all) number of 
      errors in the Radial eight-arm maze test. A combined supplementation of vitamin 
      B12, folic acid, and omega-3 fatty acids improved the levels of LCPUFA, 
      neurotrophins, and cognition. A maternal diet consisting of high levels of 
      folate, vitamin B12, and DHA reduced the risk for cognitive disorders in the 
      adult offspring in an animal model of pregnancy-induced hypertension.
FAU - Kemse, Nisha
AU  - Kemse N
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth (Deemed to be University), Pune 411043, India. 
      srjoshi62@gmail.com.
FAU - Kale, Anvita
AU  - Kale A
FAU - Chavan-Gautam, Preeti
AU  - Chavan-Gautam P
FAU - Joshi, Sadhana
AU  - Joshi S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/psychology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*drug effects
MH  - Dietary Supplements/analysis
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Female
MH  - Folic Acid/*administration & dosage
MH  - Hippocampus/drug effects/metabolism
MH  - Hypertension, Pregnancy-Induced/*drug therapy/metabolism
MH  - Male
MH  - Maze Learning
MH  - Pedigree
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/etiology/*psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Vitamin B 12/*administration & dosage
EDAT- 2018/06/30 06:00
MHDA- 2018/10/30 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
AID - 10.1039/c8fo00467f [doi]
PST - ppublish
SO  - Food Funct. 2018 Jul 17;9(7):3872-3883. doi: 10.1039/c8fo00467f.