PMID- 29956690
OWN - NLM
STAT- MEDLINE
DCOM- 20181214
LR  - 20220321
IS  - 1998-4049 (Electronic)
IS  - 1319-3767 (Print)
IS  - 1319-3767 (Linking)
VI  - 24
IP  - 5
DP  - 2018 Sep-Oct
TI  - Genetic susceptibility for celiac disease is highly prevalent in the Saudi 
      population.
PG  - 268-273
LID - 10.4103/sjg.SJG_551_17 [doi]
AB  - BACKGROUND/AIM: To determine the frequency of celiac disease (CD)-predisposing 
      human leukocyte antigen (HLA)-DQ genotypes in the Saudi population, where the 
      prevalence of CD is 1.5% as recently reported in a mass screening study. PATIENTS 
      AND METHODS: In a cross-sectional population-based study, a total of 192 randomly 
      selected healthy school children (97 females, mean age 10.5 +/- 2.2 years, all 
      negative for tissue transglutaminase-IgA) were typed for D QA1 and D QB1 genes by 
      polymerase chain reaction sequence-specific oligonucleotide probes. RESULTS: Of 
      the 192 children, 52.7% carried the high-risk CD-associated HLA-DQ molecules: 
      homozygous DQ2.5 ( 2.6%), DQ2.5/DQ2.2 ( 4.7%), heterozygous DQ2.5 ( 28.15%), 
      homozygous DQ8 ( 4.2%), DQ8/DQ2.2 ( 3.6%), and double dose DQ2.2 ( 9.4%). 
      Low-risk CD-associated HLA-DQ molecules (single dose DQ2.2 and heterozygous DQ8) 
      constituted 3.6% and 9.4%, respectively. Among the very low-risk groups, 
      individuals lacking alleles that contribute to DQ2/DQ8 variants (33.5%), 13.5% 
      carried only one of the alleles of the high-risk HLA-DQ2.5 heterodimer called 
      "half-heterodimer" (HLA-DQA1*05 in 12% and HLA-DQB1* 02 in 1.5%), and 20.8% 
      lacked all the susceptible alleles (DQX.x). Gender distribution was not 
      significantly different among the CD-risk groups. CONCLUSION: We report one of 
      the highest frequencies of CD-predisposing HLA-DQ genotypes among healthy general 
      populations (52.7%) worldwide, which might partly explain the high prevalence of 
      CD in the Saudi community.
FAU - Al-Hussaini, Abdulrahman
AU  - Al-Hussaini A
AD  - Division of Pediatric Gastroenterology, Children's Specialized Hospital, King 
      Fahad Medical City; College of Medicine, Alfaisal University; Prince Abdullah bin 
      Khalid Celiac Disease Research Chair, Department of Pediatrics, Faculty of 
      Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
FAU - Alharthi, Hanan
AU  - Alharthi H
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
FAU - Osman, Awad
AU  - Osman A
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
FAU - Eltayeb-Elsheikh, Nezar
AU  - Eltayeb-Elsheikh N
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
FAU - Chentoufi, Aziz
AU  - Chentoufi A
AD  - Department of Immunology, University of Mohammed VI for health sciences, 
      Casablanca, Morocco.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Gastroenterol
JT  - Saudi journal of gastroenterology : official journal of the Saudi 
      Gastroenterology Association
JID - 9516979
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
SB  - IM
CIN - Saudi J Gastroenterol. 2018 Sep-Oct;24(5):257-258. PMID: 30178779
MH  - Alleles
MH  - Celiac Disease/epidemiology/*genetics
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Saudi Arabia/epidemiology
PMC - PMC6152002
OTO - NOTNLM
OT  - Celiac disease
OT  - HLA typing
OT  - HLA-DQ2.5
OT  - HLA-DQ8
OT  - Saudi Arabia
OT  - genetic susceptibility
COIS- There are no conflicts of interest
EDAT- 2018/06/30 06:00
MHDA- 2018/12/15 06:00
PMCR- 2018/09/01
CRDT- 2018/06/30 06:00
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2018/12/15 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 235582 [pii]
AID - SJG-24-268 [pii]
AID - 10.4103/sjg.SJG_551_17 [doi]
PST - ppublish
SO  - Saudi J Gastroenterol. 2018 Sep-Oct;24(5):268-273. doi: 10.4103/sjg.SJG_551_17.