PMID- 29956832
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 33
IP  - 2
DP  - 2019 Feb
TI  - Simultaneous determination of eight components in Angelica sinensis based on 
      UHPLC-ESI-MS/MS method for quality evaluation.
PG  - e4326
LID - 10.1002/bmc.4326 [doi]
AB  - A method employing ultra-high performance liquid chromatography-tandem mass 
      spectrometry (UHPLC-MS/MS) for determination of eight components including 
      ferulic acid, senkyunolide A, butylphthalide, ligustilide, butylidenephalide, 
      senkyunolide I, senkyunolide H and levistolide A in Angelica sinensis was 
      established. The separation was carried out using a Waters ACQUITY UHPLC BEH 
      C(18) column with gradient elution with 0.1% formic acid aqueous and acetonitrile 
      at a flow rate of 0.4 mL/min. Good linearity was attained with R(2) of 
      0.9983-0.9998 in wide concentration ranges. The method had limit of detection 
      (LOD) and quantitation (LOQ) in the range of 0.42-6.98 ng/mL and 
      1.39-23.28 ng/mL, respectively. Intra- and inter-day precisions varied with 
      relative standard deviations (RSDs) from 0.33% to 0.88% and 0.37% to 1.04%, 
      respectively. Moreover, the average recoveries were in a satisfactory range of 
      92.7%-102.1% with RSDs of less than 3.60%. Finally, the method was successfully 
      applied to analyze 19 batches of A. sinensis samples grown in Min County, Gansu 
      province, China, as well as that collected in other regions. The findings 
      indicated that the established method is reliable and may thus be applied as a 
      powerful tool for qualitative and quantitative analysis of components in A. 
      sinensis, which has its implications in quality control of A. sinensis.
CI  - (c) 2018 John Wiley & Sons, Ltd.
FAU - Gui, Qiaodi
AU  - Gui Q
AUID- ORCID: 0000-0003-0884-7065
AD  - Clinical Laboratory, Shaanxi Provincial People's Hospital, Shaanxi, China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Clinical Laboratory, Xi'an No. 5 Hospital, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20181105
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Angelica sinensis/*chemistry
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Limit of Detection
MH  - Linear Models
MH  - Plant Extracts/*analysis/chemistry
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Angelica sinensis
OT  - UHPLC-ESI-MS/MS
OT  - quality evaluation
EDAT- 2018/06/30 06:00
MHDA- 2019/02/26 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/02/01 00:00 [received]
PHST- 2018/05/06 00:00 [revised]
PHST- 2018/06/20 00:00 [accepted]
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
AID - 10.1002/bmc.4326 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2019 Feb;33(2):e4326. doi: 10.1002/bmc.4326. Epub 2018 Nov 5.