PMID- 29957388
OWN - NLM
STAT- MEDLINE
DCOM- 20191003
LR  - 20191007
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 321
DP  - 2018 Aug 15
TI  - Differences in neuroimmune signalling between male and female patients suffering 
      from knee osteoarthritis.
PG  - 49-60
LID - S0165-5728(18)30034-1 [pii]
LID - 10.1016/j.jneuroim.2018.05.009 [doi]
AB  - The primary aim was to identify cytokines involved in blood borne, neuroimmune 
      joint-to-CNS signalling in knee osteoarthritis (OA) patients. Monocyte 
      chemoattractant protein 1 (MCP1) and Interleukin-8 (IL-8) were elevated in the 
      cerebrospinal fluid (CSF) in patients indicating neuroinflammation. Significant 
      positive correlations were found for MCP1 across CSF, serum and synovial fluid 
      (SF), in female, but not male patients. The results revealed sex differences in 
      neuroimmune signalling and implicated MCP1 in blood borne joint-to-CNS signalling 
      in female patients. Symptom severity correlated with IL-6 and IL-8 levels in SF, 
      but was inversely associated with IL-6 and IL-8 levels in CSF, indicating that 
      neuroinflammation in OA may be an adaptive, possibly neuroprotective mechanism 
      promoting symptom reduction.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Kosek, E
AU  - Kosek E
AD  - Department of Clinical Neuroscience, Karolinska Insitutet, Department of 
      Neuroradiology, Karolinska University Hospital, SE-171 77 Stockholm, Sweden; 
      Stockholm Spine Center, SE-194 89 Stockholm, Sweden. Electronic address: 
      Eva.Kosek@ki.se.
FAU - Finn, A
AU  - Finn A
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 
      Stockholm, Sweden.
FAU - Ultenius, C
AU  - Ultenius C
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 
      Stockholm, Sweden.
FAU - Hugo, A
AU  - Hugo A
AD  - Ortho Center Stockholm, Lowenstromska Hospital, 194 89 Upplands Vasby, Sweden.
FAU - Svensson, C
AU  - Svensson C
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 
      Stockholm, Sweden.
FAU - Ahmed, A S
AU  - Ahmed AS
AD  - Department of Clinical Neuroscience, Karolinska Insitutet, Department of 
      Neuroradiology, Karolinska University Hospital, SE-171 77 Stockholm, Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180525
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Neuroimmunomodulation/*physiology
MH  - Osteoarthritis, Knee/*blood/*immunology
MH  - Pain Measurement/methods
MH  - *Sex Characteristics
MH  - Signal Transduction/physiology
EDAT- 2018/06/30 06:00
MHDA- 2019/10/08 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/04/23 00:00 [revised]
PHST- 2018/05/18 00:00 [accepted]
PHST- 2018/06/30 06:00 [entrez]
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
AID - S0165-5728(18)30034-1 [pii]
AID - 10.1016/j.jneuroim.2018.05.009 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2018 Aug 15;321:49-60. doi: 10.1016/j.jneuroim.2018.05.009. Epub 
      2018 May 25.