PMID- 29957471
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 106
DP  - 2018 Oct
TI  - Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, beta-amyloid 
      deposition, and neuroinflammation in the SAMP8 mice.
PG  - 92-97
LID - S0753-3322(18)31477-X [pii]
LID - 10.1016/j.biopha.2018.06.106 [doi]
AB  - beta-amyloid deposition and neuroinflammation play a crucial part in Alzheimer's 
      disease. Therefore, this study was designed to find the effects of 
      1-deoxynojirimycin (DNJ) purified from mulberry leaves on pathological deposition 
      of Abeta peptides and neuroinflammation in senescence-accelerated-prone mouse 8 
      (SAMP8) mice. Compared to senescence-accelerated-resistant mouse 1 (SAMR1) mice, 
      SAMP8 mice exhibited conspicuous declines in spatial memory abilities and 
      brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptors (TrkB) 
      level in hippocampus; increased Abeta deposition, beta-secretase (BACE1) level, 
      microglia activation and inflammatory factors, including interleukin-1beta (IL-1beta), 
      interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in the brain. The SAMP8 
      mice were treated with DNJ (40 or 160 mg/kg/day) by oral administration for two 
      months. Our results indicated that DNJ treatment improved these changes, and the 
      160-mg/kg/day DNJ group revealed more significant alleviation. Therefore, DNJ 
      potentially has the neuroprotective effect by inhibiting BACE1 expression, 
      attenuating Abeta deposition, remitting neuroinflammation, and up-regulating the 
      BDNF/TrkB signal pathway in the brain.
CI  - Copyright (c) 2018. Published by Elsevier Masson SAS.
FAU - Chen, Weike
AU  - Chen W
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
FAU - Liang, Tingting
AU  - Liang T
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
FAU - Zuo, Wenwen
AU  - Zuo W
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
FAU - Wu, Xin
AU  - Wu X
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
FAU - Shen, Zibo
AU  - Shen Z
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
FAU - Wang, Fang
AU  - Wang F
AD  - College of Food Science and Engineering, Nanjing University of Finance and 
      Economics, Nanjing, 210023, China.
FAU - Li, Cunyu
AU  - Li C
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China; 
      Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing, 210023, China.
FAU - Zheng, Yunfeng
AU  - Zheng Y
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China; 
      Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing, 210023, China.
FAU - Peng, Guoping
AU  - Peng G
AD  - Pharmacy College, Nanjing University of Chinese Medicine, Nanjing, 210023, China; 
      Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing, 210023, China. Electronic address: 
      guopingpeng@sohu.com.
LA  - eng
PT  - Journal Article
DEP - 20180626
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neuroprotective Agents)
RN  - 19130-96-2 (1-Deoxynojirimycin)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - EC 3.4.23.46 (Bace1 protein, mouse)
SB  - IM
MH  - 1-Deoxynojirimycin/*pharmacology
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Aspartic Acid Endopeptidases/metabolism
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*drug effects
MH  - Cognitive Dysfunction/metabolism/pathology/*prevention & control/psychology
MH  - Disease Models, Animal
MH  - Encephalitis/metabolism/pathology/*prevention & control/psychology
MH  - Hippocampus/*drug effects/metabolism/pathology/physiopathology
MH  - Inflammation Mediators/metabolism
MH  - Male
MH  - Membrane Glycoproteins/metabolism
MH  - Memory/drug effects
MH  - Mice, Inbred Strains
MH  - Microglia/drug effects/metabolism/pathology
MH  - Neuroprotective Agents/*pharmacology
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Signal Transduction/drug effects
MH  - Time Factors
OTO - NOTNLM
OT  - 1-Deoxynojirimycin
OT  - Abeta deposition
OT  - BDNF/TrkB
OT  - Microglia
OT  - Neuroinflammation
OT  - SAMP8 mice
EDAT- 2018/06/30 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/06/18 00:00 [revised]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
AID - S0753-3322(18)31477-X [pii]
AID - 10.1016/j.biopha.2018.06.106 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Oct;106:92-97. doi: 10.1016/j.biopha.2018.06.106. Epub 
      2018 Jun 26.