PMID- 29957739
OWN - NLM
STAT- MEDLINE
DCOM- 20190920
LR  - 20190920
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 95
IP  - 7
DP  - 2018 Jul
TI  - Interocular Asymmetry of the Ganglion Cell-inner Plexiform Layer in Diabetic 
      Retinopathy.
PG  - 594-601
LID - 10.1097/OPX.0000000000001242 [doi]
AB  - SIGNIFICANCE: The interocular difference in the ganglion cell-inner plexiform 
      layer thickness showed a significant correlation with the diabetic retinopathy 
      (DR) severity. PURPOSE: The purpose of this study was to analyze the interocular 
      differences in the foveal, retinal nerve fiber layer (RNFL), and ganglion 
      cell-inner plexiform layer (GC-IPL) thickness of DR patients using 
      spectral-domain optical coherence tomography. METHODS: A total of 508 eyes from 
      254 patients with different severities of DR and 184 eyes from 92 control 
      subjects were included. The GC-IPL, foveal, and RNFL thicknesses were measured, 
      and the interocular differences in these thicknesses were correlated in control 
      subjects and DR patients. RESULTS: The interocular difference in the average 
      GC-IPL thickness significantly increased with the severity of DR. The interocular 
      differences in the average GC-IPL thicknesses of the severe nonproliferative DR 
      (NPDR) and the proliferative DR patients were significantly higher than those of 
      the control group. However, there was no significant difference in thickness 
      between the control group and the group with mild to moderate NPDR. In the group 
      with proliferative DR, the interocular difference in the average GC-IPL was 
      greater than those in the central foveal and RNFL thicknesses. Multivariate 
      regression analyses showed that the DR severity and the interocular difference in 
      central foveal thickness were significantly correlated with the interocular 
      difference in the average GC-IPL thickness. CONCLUSIONS: The interocular 
      differences in the central foveal, RNFL, and GC-IPL thicknesses significantly 
      increased with increased DR severity. However, there was no significant 
      difference between the control group and the group with mild to moderate NPDR. 
      The GC-IPL differences showed a significant correlation with DR severity. These 
      findings may be an indicator of DR progression.
FAU - Lim, Hyung Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
AD  - Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Republic of 
      Korea *kimjy@cnu.ac.kr.
FAU - Lee, Woo Hyuk
AU  - Lee WH
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Jo, Young Joon
AU  - Jo YJ
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Kim, Jung Yeul
AU  - Kim JY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/diagnostic imaging/*pathology
MH  - Disease Progression
MH  - Female
MH  - Fovea Centralis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
EDAT- 2018/06/30 06:00
MHDA- 2019/09/21 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2019/09/21 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
AID - 10.1097/OPX.0000000000001242 [doi]
PST - ppublish
SO  - Optom Vis Sci. 2018 Jul;95(7):594-601. doi: 10.1097/OPX.0000000000001242.