PMID- 29958011
OWN - NLM
STAT- MEDLINE
DCOM- 20200507
LR  - 20200507
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 56
IP  - 6
DP  - 2019 Jun
TI  - Efficacy and safety of the combination fluticasone propionate plus salmeterol in 
      asthmatic preschoolers: An observational study.
PG  - 573-580
LID - 10.1080/02770903.2018.1474923 [doi]
AB  - BACKGROUND: Inhaled Corticosteroids (ICS) are the cornerstone of asthma 
      management in pediatric patients. However, in some cases, asthma is not 
      adequately controlled on ICS alone. Long-acting beta(2)-agonists (LABA) are one 
      of the available additional therapies but their use has rarely been studied among 
      children younger than 5 years. OBJECTIVE: The aim of this observational study was 
      to evaluate the efficacy and safety of the combination of fluticasone propionate 
      and salmeterol (FP/SA) in asthmatic children younger than 5 years of age. 
      METHODS: A retrospective study of 796 children under the age of 5 years (2.87 +/- 
      1.22 years, 64.2% males), who were treated with FP/SA was conducted. 
      Hospitalization rates, frequency of wheezing, exercise induced asthma, nocturnal 
      wheeze and drug-related side-effects were recorded through children's medical 
      records. RESULTS: The children had previously received short-acting beta(2)-agonists 
      (73%), ICS (17%), montelukast (1%), and ICS with montelukast (2%). Mean duration 
      of therapy with FP/SA was 12.45 +/- 9.14 months. After adjusting for age, gender, 
      and duration of treatment, a 89% reduction was recorded in annual hospitalization 
      rates (from 27.13% before treatment to 3.01% after FP/SA therapy, p < 0.001), a 
      71% reduction in incidence of exercise-induced asthma (36.8% vs. after 10.6%, p < 
      0.001), a 81% reduction in nocturnal asthma (33.7% vs. after: 6.4%, p < 0.001), 
      as well as in frequency of wheezing (p < 0.01),. No previous treatment carry-on 
      effect was observed. No major drug-related side-effects occurred in the study 
      group. CONCLUSIONS: Combination therapy (FP/SA) is well-tolerated and highly 
      effective in asthmatic children under the age of 5 years.
FAU - Hatziagorou, Elpis
AU  - Hatziagorou E
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Kouroukli, Eleana
AU  - Kouroukli E
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Galogavrou, Maria
AU  - Galogavrou M
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Papanikolaou, Dafni
AU  - Papanikolaou D
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Terzi, Dr Despoina
AU  - Terzi DD
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Anagnostopoulou, Pinelopi
AU  - Anagnostopoulou P
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Kirvassilis, Fotios
AU  - Kirvassilis F
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
FAU - Panagiotakos, Demosthenes B
AU  - Panagiotakos DB
AUID- ORCID: 0000-0001-8583-153X
AD  - b Harokopio University, School of Health Science and Education , Athens , Greece.
FAU - Tsanakas, John
AU  - Tsanakas J
AD  - a Aristotle University of Thessaloniki , Greece, Paediatric Pulmonology Unit, 
      Hippokration Hospital , Thessaloniki , Greece.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180629
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Fluticasone-Salmeterol Drug Combination)
SB  - IM
MH  - Asthma/*drug therapy
MH  - Bronchodilator Agents/adverse effects/*therapeutic use
MH  - Child, Preschool
MH  - Female
MH  - Fluticasone-Salmeterol Drug Combination/adverse effects/*therapeutic use
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Asthma
OT  - children
OT  - inhaled corticosteroids with long-acting beta-agonists
EDAT- 2018/06/30 06:00
MHDA- 2020/05/08 06:00
CRDT- 2018/06/30 06:00
PHST- 2018/06/30 06:00 [pubmed]
PHST- 2020/05/08 06:00 [medline]
PHST- 2018/06/30 06:00 [entrez]
AID - 10.1080/02770903.2018.1474923 [doi]
PST - ppublish
SO  - J Asthma. 2019 Jun;56(6):573-580. doi: 10.1080/02770903.2018.1474923. Epub 2018 
      Jun 29.