PMID- 29958117 OWN - NLM STAT- MEDLINE DCOM- 20190306 LR - 20190306 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 119 DP - 2018 Oct TI - Determinants of plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances in pregnant women from a birth cohort in Shanghai, China. PG - 165-173 LID - S0160-4120(18)30269-1 [pii] LID - 10.1016/j.envint.2018.06.015 [doi] AB - Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are widely used in commercial applications and have been commonly detected in pregnant women in Europe and North America. However, data on PFAS concentrations in pregnant women in China are limited. Additionally, the determinants of maternal PFAS concentrations with respect to diet habits have been less extensively described, especially in Asian countries. In the present study, we aimed to measure PFAS concentrations in pregnant women and evaluate sociodemographic, lifestyle, and dietary factors as potential determinants of PFAS concentrations. We analyzed eleven PFASs in maternal blood samples (N = 981) collected at 12-16 weeks of gestation between April and December 2012 at Maternal and Child Health Hospital of Minhang District in Shanghai, China. Multivariate linear regression models were used to examine the associations of PFAS concentrations with maternal sociodemographic, lifestyle, and dietary factors. Eight PFASs, including perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), and perfluorotridecanoic acid (PFTrDA), were detected in >85% of the samples. PFOA and PFOS were the predominant PFASs with high median concentrations (19.97 ng/mL and 10.81 ng/mL, respectively). Pregnant women who were older, multiparous, well educated, passive smokers, with lower per capita household incomes, and had lived in rooms decorated within the past two years had higher PFAS concentrations, after mutual adjustment for maternal sociodemographic characteristics and lifestyles. With regard to dietary factors, intake of red meat, poultry, animal offal, fish, pastries and fried food, and drinking tap water during pregnancy contributed to higher concentrations of most PFASs, after adjustment for sociodemographic characteristics and lifestyles. Furthermore, higher intake of wheat, coarse cereals, tubers, and soy products was associated with lower maternal PFAS concentrations. Our findings indicate that PFASs were ubiquitous among pregnant women in Shanghai. We provide new evidence for the association between dietary factors and maternal PFAS exposure in China. CI - Copyright (c) 2018. Published by Elsevier Ltd. FAU - Tian, Youping AU - Tian Y AD - School of Public Health, Fudan University, Shanghai 200032, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Zhou, Yan AU - Zhou Y AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. FAU - Miao, Maohua AU - Miao M AD - Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Wang, Ziliang AU - Wang Z AD - School of Public Health, Fudan University, Shanghai 200032, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Yuan, Wei AU - Yuan W AD - Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Liu, Xiao AU - Liu X AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. FAU - Wang, Xin AU - Wang X AD - Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Wang, Zhikai AU - Wang Z AD - Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. FAU - Wen, Sheng AU - Wen S AD - National Reference Laboratory of Dioxin, Institute of Health Inspection and Detection, Hubei Provincial Academy of Preventive Medicine, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China. Electronic address: wenshenggy@aliyun.com. FAU - Liang, Hong AU - Liang H AD - Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China. Electronic address: lucylhcn@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180627 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - China MH - Cohort Studies MH - Diet MH - *Environmental Exposure/analysis/statistics & numerical data MH - Environmental Pollutants/*blood MH - Female MH - Fluorocarbons/*blood MH - Humans MH - Models, Statistical MH - Pregnancy OTO - NOTNLM OT - China OT - Determinants OT - PFASs OT - Pregnant women EDAT- 2018/06/30 06:00 MHDA- 2019/03/07 06:00 CRDT- 2018/06/30 06:00 PHST- 2018/02/11 00:00 [received] PHST- 2018/06/12 00:00 [revised] PHST- 2018/06/13 00:00 [accepted] PHST- 2018/06/30 06:00 [pubmed] PHST- 2019/03/07 06:00 [medline] PHST- 2018/06/30 06:00 [entrez] AID - S0160-4120(18)30269-1 [pii] AID - 10.1016/j.envint.2018.06.015 [doi] PST - ppublish SO - Environ Int. 2018 Oct;119:165-173. doi: 10.1016/j.envint.2018.06.015. Epub 2018 Jun 27.