PMID- 29958988
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20240109
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 120
DP  - 2018 Oct
TI  - Residue analysis and dietary exposure risk assessment of tebufenozide in stem 
      lettuce (Lactuca sativa L. var. angustana Irish).
PG  - 64-70
LID - S0278-6915(18)30431-9 [pii]
LID - 10.1016/j.fct.2018.06.057 [doi]
AB  - Tebufenozide, a newly-developed nonsteroidal ecdysone agonist, is in 
      pre-regulation phase (before approval for use) on stem lettuce in China. Aiming 
      at the safe application of tebufenozide, the dissipation and terminal residue 
      trials on stem lettuce were performed under good agricultural practice (GAP). The 
      dissipation trials shown that tebufenozide was rapidly degraded in stem lettuce, 
      with half-lives of 5.0-8.2 days. Pre-regulation dietary exposure risk assessments 
      were evaluated to recommend maximum residue limits (MRLs) based on risk quotients 
      (RQ) method. Relevant toxicological parameters including ADI (acceptable daily 
      intake) and ARfD (acute reference dose) were applied to assess the potential 
      dietary exposure risk. The results indicated the chronic dietary exposure risk 
      probability (RQc) of tebufenozide ranged from 36.4% to 70.0%. The acute dietary 
      exposure risk probability (RQa) of tebufenozide was 2.88%-8.49% in lettuce stems 
      and 14.0%-20.0% in lettuce leaves, respectively. On the basis of supervised field 
      trial data and dietary exposure risk assessment results, the MRLs of tebufenozide 
      were recommended as 3 mg/kg for lettuce stems and 10 mg/kg for lettuce leaves, 
      respectively. The results demonstrated that the dietary exposure risk of 
      tebufenozide used in stem lettuce under GAP was negligible and would not pose 
      unacceptable health risk to Chinese consumers.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Lin, Hongfang
AU  - Lin H
AD  - School of Chemistry and Biological Engineering, University of Science and 
      Technology Beijing, Beijing, 100083, PR China. Electronic address: 
      hongfanglin1991@163.com.
FAU - Liu, Xinze
AU  - Liu X
AD  - School of Chemistry and Biological Engineering, University of Science and 
      Technology Beijing, Beijing, 100083, PR China. Electronic address: 
      ustblxz@gmail.com.
FAU - Ma, Yecheng
AU  - Ma Y
AD  - School of Chemistry and Biological Engineering, University of Science and 
      Technology Beijing, Beijing, 100083, PR China. Electronic address: 
      myc19930309@163.com.
FAU - Pang, Kyongjin
AU  - Pang K
AD  - School of Chemistry and Biological Engineering, University of Science and 
      Technology Beijing, Beijing, 100083, PR China. Electronic address: 
      banggyongjin@163.com.
FAU - Hu, Jiye
AU  - Hu J
AD  - School of Chemistry and Biological Engineering, University of Science and 
      Technology Beijing, Beijing, 100083, PR China. Electronic address: 
      jyhu@ustb.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180626
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Hydrazines)
RN  - 0 (Insecticides)
RN  - 0 (Pesticide Residues)
RN  - TNN5MI5EKF (tebufenozide)
SB  - IM
MH  - China
MH  - Chromatography, Liquid
MH  - *Dietary Exposure
MH  - Ecosystem
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Hydrazines/*analysis/toxicity
MH  - Insecticides/*analysis/toxicity
MH  - Lactuca/*chemistry
MH  - Pesticide Residues/*analysis/toxicity
MH  - Plant Leaves/chemistry
MH  - Plant Stems/chemistry
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Dietary exposure risk assessment
OT  - LC-MS/MS
OT  - Stem lettuce
OT  - Tebufenozide
EDAT- 2018/07/01 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/07/01 06:00
PHST- 2018/01/30 00:00 [received]
PHST- 2018/06/13 00:00 [revised]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/07/01 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2018/07/01 06:00 [entrez]
AID - S0278-6915(18)30431-9 [pii]
AID - 10.1016/j.fct.2018.06.057 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2018 Oct;120:64-70. doi: 10.1016/j.fct.2018.06.057. Epub 2018 
      Jun 26.