PMID- 29959025
OWN - NLM
STAT- MEDLINE
DCOM- 20190912
LR  - 20210109
IS  - 1943-7811 (Electronic)
IS  - 1525-1578 (Print)
IS  - 1525-1578 (Linking)
VI  - 20
IP  - 5
DP  - 2018 Sep
TI  - Characterization of 108 Genomic DNA Reference Materials for 11 Human Leukocyte 
      Antigen Loci: A GeT-RM Collaborative Project.
PG  - 703-715
LID - S1525-1578(18)30111-9 [pii]
LID - 10.1016/j.jmoldx.2018.05.009 [doi]
AB  - The highly polymorphic human leukocyte antigen (HLA) genes, located in the human 
      major histocompatibility complex, encode the class I and II antigen-presenting 
      molecules, which are centrally involved in the immune response. HLA typing is 
      used for several clinical applications, such as transplantation, 
      pharmacogenetics, and diagnosis of autoimmune disease. HLA typing is highly 
      complex because of the homology of HLA genes and pseudogenes and the extensive 
      polymorphism in the population. The Centers for Disease Control and Prevention 
      established the Genetic Testing Reference Materials Coordination Program (GeT-RM) 
      in partnership with the genetics community to improve the availability of genomic 
      DNA reference materials necessary for quality assurance of genetic laboratory 
      testing. The GeT-RM together with three clinical laboratories and the Coriell 
      Cell Repositories have characterized genomic DNA obtained from a panel of 108 
      cell lines for all HLA classic polymorphic loci: HLA-A, B, C, DRB1, DRB3, DRB4, 
      DRB5, DQA1, DQB1, DPA1, and DPB1. The goal was to develop a publicly available 
      and renewable source of well-characterized genomic DNA reference materials to 
      support molecular HLA typing assay development, validation, and verification, 
      quality control, and proficiency testing. These genomic DNA samples are publicly 
      available from the National Institutes of General Medical Science Repository at 
      the Coriell Cell Repositories.
CI  - Copyright (c) 2018 American Society for Investigative Pathology and the Association 
      for Molecular Pathology. Published by Elsevier Inc. All rights reserved.
FAU - Bettinotti, Maria P
AU  - Bettinotti MP
AD  - Immunogenetics Laboratory, Department of Medicine, Johns Hopkins School of 
      Medicine, Baltimore, Maryland.
FAU - Ferriola, Deborah
AU  - Ferriola D
AD  - Department of Pathology and Laboratory Medicine, The Children's Hospital of 
      Philadelphia, Philadelphia, Pennsylvania.
FAU - Duke, Jamie L
AU  - Duke JL
AD  - Department of Pathology and Laboratory Medicine, The Children's Hospital of 
      Philadelphia, Philadelphia, Pennsylvania.
FAU - Mosbruger, Timothy L
AU  - Mosbruger TL
AD  - Department of Pathology and Laboratory Medicine, The Children's Hospital of 
      Philadelphia, Philadelphia, Pennsylvania.
FAU - Tairis, Nikolaos
AU  - Tairis N
AD  - Department of Pathology and Laboratory Medicine, The Children's Hospital of 
      Philadelphia, Philadelphia, Pennsylvania.
FAU - Jennings, Lawrence
AU  - Jennings L
AD  - Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois.
FAU - Kalman, Lisa V
AU  - Kalman LV
AD  - Division of Laboratory Systems, Centers for Disease Control and Prevention, 
      Atlanta, Georgia. Electronic address: LKalman@cdc.gov.
FAU - Monos, Dimitri
AU  - Monos D
AD  - Department of Pathology and Laboratory Medicine, The Children's Hospital of 
      Philadelphia, Philadelphia, Pennsylvania; Department of Pathology and Laboratory 
      Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania.
LA  - eng
GR  - CC999999/ImCDC/Intramural CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180626
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
RN  - 0 (HLA Antigens)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Cell Line
MH  - *Cooperative Behavior
MH  - DNA/*genetics
MH  - *Genetic Loci
MH  - Genetic Testing/*methods/*standards
MH  - *Genome, Human
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Reference Standards
PMC - PMC6939753
MID - NIHMS1062729
EDAT- 2018/07/01 06:00
MHDA- 2019/09/13 06:00
PMCR- 2020/01/02
CRDT- 2018/07/01 06:00
PHST- 2018/03/12 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/21 00:00 [accepted]
PHST- 2018/07/01 06:00 [pubmed]
PHST- 2019/09/13 06:00 [medline]
PHST- 2018/07/01 06:00 [entrez]
PHST- 2020/01/02 00:00 [pmc-release]
AID - S1525-1578(18)30111-9 [pii]
AID - 10.1016/j.jmoldx.2018.05.009 [doi]
PST - ppublish
SO  - J Mol Diagn. 2018 Sep;20(5):703-715. doi: 10.1016/j.jmoldx.2018.05.009. Epub 2018 
      Jun 26.