PMID- 29959897
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20220408
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 485
DP  - 2018 Oct
TI  - Tumor necrosis factor-alpha and diabetic retinopathy: Review and meta-analysis.
PG  - 210-217
LID - S0009-8981(18)30314-0 [pii]
LID - 10.1016/j.cca.2018.06.028 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is produced by multinuclear giant 
      cells and acts as local intensification signals in pathological processes 
      associated with chronic eye inflammation. This meta-analysis was performed to 
      provide a better understanding of the relationship between TNF-alpha and diabetic 
      retinopathy (DR). METHOD: Online electric databases were searched to retrieve all 
      relevant articles published before October 2017. The standard mean difference 
      (SMD) and their 95% confidence intervals (CI) were included and then pooled with 
      a random effects model. RESULTS: A total of 16 articles with 1286 participants 
      were included in this meta-analysis. No difference in the level of TNF-alpha was 
      found between DR patients and healthy controls (SMD = 0.39, 95% CI = -0.09 to 
      0.68, P = 0.01). Subgroup analysis showed that with respect to the level of 
      TNF-alpha, the association was significant for studies conducted in Europe (SMD: 
      0.57, 95% CI: 0.11-1.02, P = 0.01), patients with type 1 DM (SMD: 1.06, 95% CI: 
      0.09-2.04, P = 0.03), studies based on serum samples (SMD: 0.57, 95% CI: 
      0.12-1.02, P = 0.01) and studies with a sample size >50 (SMD: 0.39, 95% CI: 
      0.03-0.75, P = 0.04). CONCLUSION: The results this meta-analysis indicated that 
      the level of TNF-alpha in DR patients was significantly different from that in the 
      healthy controls, so TNF-alpha represents a candidate biomarker for DR.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Yao, Yang
AU  - Yao Y
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, 
      PR China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an 
      Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi 710061, PR 
      China.
FAU - Li, Rong
AU  - Li R
AD  - Department of Ophthalmology, The First Affiliated Hospital, Xi'an Medical 
      University, Xi'an, Shaanxi 710077, PR China.
FAU - Du, Junhui
AU  - Du J
AD  - Department of Ophthalmology, Xi'an Ninth Hospital, Medical College of Xi'an 
      Jiaotong University, Xi'an, Shanxi 710054, China.
FAU - Li, Xiangnan
AU  - Li X
AD  - Clinical Medicine (Four-year program) of Grade 2014, Xi'an Medical University, 
      Xi'an 710021, PR China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer 
      Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
FAU - Long, Lihui
AU  - Long L
AD  - Department of pharmacy, The First Affiliated Hospital, Xi'an Medical University, 
      Xi'an, Shaanxi 710077, PR China.
FAU - Li, Dongmin
AU  - Li D
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, 
      PR China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an 
      Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi 710061, PR 
      China. Electronic address: lidongm@mail.xjtu.edu.cn.
FAU - Lu, Shemin
AU  - Lu S
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medical 
      Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, 
      PR China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an 
      Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi 710061, PR 
      China. Electronic address: lushemin@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180628
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Biomarkers/blood
MH  - Diabetic Retinopathy/*blood
MH  - Humans
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Meta-analysis
OT  - Tumor necrosis factor-alpha
EDAT- 2018/07/01 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/07/01 06:00
PHST- 2018/04/20 00:00 [received]
PHST- 2018/06/16 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/07/01 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/07/01 06:00 [entrez]
AID - S0009-8981(18)30314-0 [pii]
AID - 10.1016/j.cca.2018.06.028 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Oct;485:210-217. doi: 10.1016/j.cca.2018.06.028. Epub 2018 
      Jun 28.