PMID- 29960699
OWN - NLM
STAT- MEDLINE
DCOM- 20191106
LR  - 20191106
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 57
IP  - 7
DP  - 2018 Jul
TI  - Catatonia in Children and Adolescents: A High Rate of Genetic Conditions.
PG  - 518-525.e1
LID - S0890-8567(18)30228-4 [pii]
LID - 10.1016/j.jaac.2018.03.020 [doi]
AB  - Pediatric catatonia is a rare and severe neuropsychiatric syndrome. We previously 
      reported, in 58 children and adolescents with catatonia, a high prevalence (up to 
      20%) of medical conditions, some of which have specific treatments.(1) Here we 
      extend the cohort inclusion and report the first systematic molecular genetic 
      data for this syndrome. Among the 89 patients consecutively admitted for 
      catatonia (according to the pediatric catatonia rating scale)(2) between 1993 and 
      2014, we identify 51 patients (57.3%) who had genetic laboratory testing, of whom 
      37 had single nucleotide polymorphism (SNP) microarray tests for CNVs and 14 had 
      routine genetic explorations (karyotyping and searches for specific chromosomal 
      abnormalities by fluorescence in situ hybridization [FISH]) or a specific 
      diagnosis test based on clinical history. To assess the causality of observed 
      genetic findings in each patient, we used a causality assessment score (CAUS)(3) 
      including 5 causality-support criteria on a 3-point scale (0 = absent; 1 = 
      moderate; 2 = high): the existence of similar cases in the literature; the 
      presence of a clinical contributing factor; the presence of a biological 
      contributing factor; the presence of other paraclinical symptoms; and response to 
      a specific treatment related to the suspected genetic or medical condition.
CI  - Copyright (c) 2018 American Academy of Child and Adolescent Psychiatry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Raffin, Marie
AU  - Raffin M
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France. 
      Electronic address: marie.raffin@aphp.fr.
FAU - Consoli, Angele
AU  - Consoli A
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France.
FAU - Giannitelli, Marianna
AU  - Giannitelli M
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France.
FAU - Philippe, Anne
AU  - Philippe A
AD  - INSERM U1163, Institut Imagine, Universite Rene Descartes, Paris, France.
FAU - Keren, Boris
AU  - Keren B
AD  - La Pitie-Salpetriere Hospital, Paris, France.
FAU - Bodeau, Nicolas
AU  - Bodeau N
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France.
FAU - Levinson, Douglas F
AU  - Levinson DF
AD  - Stanford University, CA.
FAU - Cohen, David
AU  - Cohen D
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France; 
      Institut des Systemes Intelligents et Robotiques, Universite Pierre et Marie 
      Curie, Paris, France.
FAU - Laurent-Levinson, Claudine
AU  - Laurent-Levinson C
AD  - Universite Pierre et Marie Curie, Hopital Pitie-Salpetriere, Paris, France; 
      Stanford University, CA.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
MH  - Adolescent
MH  - Catatonia/diagnosis/*genetics
MH  - Child
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
EDAT- 2018/07/02 06:00
MHDA- 2019/11/07 06:00
CRDT- 2018/07/02 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/03/17 00:00 [revised]
PHST- 2018/05/09 00:00 [accepted]
PHST- 2018/07/02 06:00 [entrez]
PHST- 2018/07/02 06:00 [pubmed]
PHST- 2019/11/07 06:00 [medline]
AID - S0890-8567(18)30228-4 [pii]
AID - 10.1016/j.jaac.2018.03.020 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2018 Jul;57(7):518-525.e1. doi: 
      10.1016/j.jaac.2018.03.020.