PMID- 29961353
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20190103
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 17
IP  - 7
DP  - 2018 Jul
TI  - Effectiveness and safety of dual influenza and pneumococcal vaccination versus 
      separate administration or no vaccination in older adults: a meta-analysis.
PG  - 653-663
LID - 10.1080/14760584.2018.1495077 [doi]
AB  - BACKGROUND: The advantages of dual pneumococcal and influenza vaccination in 
      older adults have not been clarified and controversy remains regarding their 
      optimal use. METHODS: This meta-analysis was conducted on 25 January 2018 using 
      PubMed, the Cochrane Library, and Embase databases. Seventeen studies were 
      selected ultimately for meta-analysis using a multi-step approach by two separate 
      authors. Primary outcomes were pneumonia, pneumococcal pneumonia, influenza, 
      hospitalization, and all-cause mortality rates, and the secondary outcome was 
      adverse effects (AEs). RESULTS: The additive preventive effects of dual in fl uenza 
      and pneumococcal vaccination versus in fl uenza vaccination alone for pneumonia and 
      death were 15% (95% confidence interval [CI]: 4-24%) and 19% (95% CI: 6-30%), 
      respectively. Compared with pneumococcal vaccination alone, dual influenza and 
      pneumococcal vaccination resulted in a 24% (95% CI: 16-31%) reduction in 
      pneumonia and a 28% (95% CI: 13-40%) reduction in death. Compared with placebo or 
      no vaccination, the effectiveness of dual vaccination was 29% (95% CI: 14-42%) 
      for pneumonia, 38% (95% CI: 25-49%) for death, 35% (95% CI: 22-46%) for 
      influenza, and 18% (95% CI: 6-29%) for hospitalization. Both vaccines showed 
      acceptable safety profiles and AEs were mild or moderate. CONCLUSION: Our 
      findings highlight the importance of concomitant influenza and pneumococcal 
      vaccination in older adults.
FAU - Yin, Mingjuan
AU  - Yin M
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
FAU - Huang, Lingfeng
AU  - Huang L
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
FAU - Yu, Na
AU  - Yu N
AD  - b Office of Research and Teaching, The Third Affiliated Hospital of GuangDong 
      Medical University (LongJiang Hospital of Shunde District Fo Shan City) , Fo Shan 
      , China.
FAU - Xu, Xiaojia
AU  - Xu X
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
FAU - Liang, Yaping
AU  - Liang Y
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
FAU - Ni, Jindong
AU  - Ni J
AD  - a Department of Epidemiology and Biostatistics , Guangdong Medical University , 
      Dongguan , China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180716
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Influenza Vaccines)
RN  - 0 (Pneumococcal Vaccines)
RN  - 0 (Vaccines, Combined)
SB  - IM
MH  - Aged
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Influenza Vaccines/*administration & dosage/adverse effects/immunology
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pneumococcal Vaccines/*administration & dosage/adverse effects/immunology
MH  - Pneumonia, Pneumococcal/epidemiology/*prevention & control
MH  - Vaccination/methods
MH  - Vaccines, Combined
OTO - NOTNLM
OT  - Effectiveness
OT  - elderly
OT  - influenza vaccination
OT  - pneumococcal vaccination
OT  - safety
EDAT- 2018/07/03 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - 10.1080/14760584.2018.1495077 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2018 Jul;17(7):653-663. doi: 10.1080/14760584.2018.1495077. 
      Epub 2018 Jul 16.