PMID- 29961447
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20230926
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70
IP  - 3
DP  - 2018 May-Jun
TI  - Pulse wave analyzed cardiovascular parameters in young first degree relatives of 
      type 2 diabetics- a cross-sectional study.
PG  - 341-345
LID - S0019-4832(16)31025-2 [pii]
LID - 10.1016/j.ihj.2017.08.013 [doi]
AB  - BACKGROUND: First degree relatives (FDR) of type 2 diabetic (T2D) are predisposed 
      for type 2 diabetes mellitus (T2DM) which accelerates cardiovascular aging. Pulse 
      wave analysis (PWA) gives non-invasive measurement of central hemodynamics like 
      central blood pressure (cBP), cardiac output (CO), stroke work (SW) and vascular 
      stiffness like pulse wave velocity (PWV) and augmentation index at heart rate 75 
      (AIx@75). OBJECTIVE: To study PWA derived cardiovascular parameters in FDRs of 
      T2D as compared to controls. MATERIALS AND METHODS: We enrolled 117 FDRs of T2D 
      and 117 matched controls for a cross-sectional study. We performed PWA using 
      Mobil-o-Graph (IEM, Germany) by oscillometric method to derive cardiovascular 
      parameters which were compared and correlated for significance. P value less than 
      0.05 was considered statistically significant. RESULTS: Gender, age, height, 
      weight, body mass index (BMI), physical activity were comparable between groups. 
      FDRs of T2D had significantly higher blood pressure (brachial-systolic 125 vs 
      118, diastolic 80 vs 77, mean 100 vs 96mmHg and central- systolic 113 vs 105, 
      diastolic 82 vs 79, pulse pressure 31 vs 28mmHg), SW (98 vs 90gm/bt), rate 
      pressure product (RPP- 113 vs 107), PWV (5.14 vs 4.89m/s), AIx@75 (30 vs 27) than 
      control. Dependant variables correlated with brachial BP more than age or 
      anthropometric variables. Result did not differ by maternal or paternal 
      inheritance in case group. CONCLUSIONS: Young, sedentary, non-obese FDRs of T2D 
      have adverse cardiovascular profile which is suggested to worsen before or with 
      onset of T2DM and definitely need attention for life style modification as 
      primary prevention.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Solanki, Jayesh D
AU  - Solanki JD
AD  - Department of Physiology, Govt Medical College, Bhavnagar, Gujarat, India. 
      Electronic address: drjaymin_83@yahoo.com.
FAU - Mehta, Hemant B
AU  - Mehta HB
AD  - Department of Physiology, Govt Medical College, Bhavnagar, Gujarat, India.
FAU - Shah, Chinmay J
AU  - Shah CJ
AD  - Department of Physiology, Govt Medical College, Bhavnagar, Gujarat, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170826
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Cardiovascular Diseases/*diagnosis/epidemiology/etiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*diagnosis/physiopathology
MH  - *Family
MH  - Follow-Up Studies
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Pulse Wave Analysis/*methods
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Young Adult
PMC - PMC6034005
OTO - NOTNLM
OT  - Cardiovascular
OT  - First degree relative
OT  - Oscillometric
OT  - Pulse wave analysis
OT  - Type 2 diabetes mellitus
EDAT- 2018/07/03 06:00
MHDA- 2018/09/06 06:00
PMCR- 2019/05/01
CRDT- 2018/07/03 06:00
PHST- 2016/12/24 00:00 [received]
PHST- 2017/07/06 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2018/07/03 06:00 [entrez]
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - S0019-4832(16)31025-2 [pii]
AID - 10.1016/j.ihj.2017.08.013 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 May-Jun;70(3):341-345. doi: 10.1016/j.ihj.2017.08.013. Epub 
      2017 Aug 26.