PMID- 29961467
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20190501
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70
IP  - 3
DP  - 2018 May-Jun
TI  - Intracoronary tenecteplase in STEMI with massive thrombus.
PG  - 446-449
LID - S0019-4832(17)30140-2 [pii]
LID - 10.1016/j.ihj.2017.08.016 [doi]
AB  - Primary percutaneous coronary intervention is the current standard of care in ST 
      elevation myocardial infarction (STEMI). However, large thrombus is an 
      independent predictor for stent thrombosis and major adverse cardiac events in 
      patients undergoing primary angioplasty for STEMI. Here we report a series of 
      STEMI patients with large thrombus burden treated successfully with low dose 
      intracoronary thrombolysis. There was prompt and early ST resolution. There was 
      improvement in thrombolysis in myocardial infarction (TIMI) flow and myocardial 
      blush grade postlysis in all patients. Majority had recanalised infarct related 
      coronary artery thus obviating the need for stenting. There was no inhospital or 
      1 month mortality or bleeding events. Hence intracoronary thrombolysis is an 
      option in patients with large thrombus burden.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Jayagopal, P B
AU  - Jayagopal PB
AD  - Lakshmi Hospital, Palakkad, Kerala, 678013, India. Electronic address: 
      jaigopallakshmi@gmail.com.
FAU - Sarjun Basha, Khadhar Mohamed
AU  - Sarjun Basha KM
AD  - Department of Cardiology, Lakshmi Hospital, Palakkad, Kerala, 678013, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170826
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - WGD229O42W (Tenecteplase)
SB  - IM
MH  - Adult
MH  - Cardiac Catheterization
MH  - Coronary Angiography
MH  - Coronary Thrombosis/*complications/diagnosis/drug therapy
MH  - Coronary Vessels
MH  - Dose-Response Relationship, Drug
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Middle Aged
MH  - ST Elevation Myocardial Infarction/diagnosis/*drug therapy/etiology
MH  - Severity of Illness Index
MH  - Tenecteplase
MH  - Thrombolytic Therapy/*methods
MH  - Tissue Plasminogen Activator/*administration & dosage
MH  - Treatment Outcome
PMC - PMC6034014
OTO - NOTNLM
OT  - Intracoronary thrombolysis
OT  - Myocardial infarction
OT  - massive thrombus
OT  - tenecteplase
EDAT- 2018/07/03 06:00
MHDA- 2018/09/06 06:00
PMCR- 2019/05/01
CRDT- 2018/07/03 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/08/18 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2018/07/03 06:00 [entrez]
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - S0019-4832(17)30140-2 [pii]
AID - 10.1016/j.ihj.2017.08.016 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 May-Jun;70(3):446-449. doi: 10.1016/j.ihj.2017.08.016. Epub 
      2017 Aug 26.