PMID- 29961695
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 45
IP  - 9
DP  - 2018 Aug
TI  - Reproducibility and Utility of the 6-minute Walk Test in Systemic Sclerosis.
PG  - 1273-1280
LID - 10.3899/jrheum.170994 [doi]
AB  - OBJECTIVE: To assess the reproducibility and the utility of the 6-minute walk 
      test (6MWT) in systemic sclerosis (SSc). METHODS: All patients with SSc who 
      underwent at least two 6MWT within a minimum 3-month interval plus simultaneous 
      routine clinical, biological, and functional evaluations were consecutively 
      enrolled in this observational study over 6 years. Following American Thoracic 
      Society guidelines, each 6MWT was repeated twice to assess the 6-minute walk 
      distance (6MWD) reproducibility, with the highest value being reported for 
      subsequent analysis. RESULTS: Among 56 (38 female) included patients aged 46 +/- SD 
      12.7 years, with 17 +/- 10 modified Rodnan skin score (mRSS) and 1 +/- 0.8 
      Scleroderma Health Assessment Questionnaire (SHAQ) at first referral, 277 6MWT 
      evaluations (5 +/- 3.9 6MWT per patient) were performed over 23 +/- 22.5 months 
      followup. Meanwhile, 8 deaths (87.5% SSc-related) occurred. The mean 6MWD 
      absolute value was 457 +/- 117 m with a 4 +/- 2.2 mean Borg dyspnea score. The 6MWD 
      intraclass correlation coefficient was 0.996 (95% CI 0.995-0.999, p < 0.0001). In 
      multivariate linear regression analysis, these factors were independently 
      associated with a lower 6MWD: sex (R(2) = 0.47, p < 0.0001), mRSS (R(2) = 0.47, p 
      = 0.008), tendon friction rub (R(2) = 0.47, p = 0.003), SHAQ (R(2) = 0.47, p = 
      0.02), muscle disability score (R(2) = 0.47, p = 0.03), DLCO% (R(2) = 0.47, p = 
      0.0008), and left ventricular ejection fraction (R(2) = 0.47, p = 0.006). The 
      6MWD at first referral was an independent predictor for the overall mortality (HR 
      0.99, 95% CI 0.988-0.999) and the SSc-related mortality (HR 0.99, 95% CI 
      0.988-0.999). CONCLUSION: We show strong reproducibility for the 6MWD and confirm 
      the 6MWT utility to assess the overall prognosis of patients with SSc.
FAU - Pugnet, Gregory
AU  - Pugnet G
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium. dominique.farge-bancel@aphp.fr pugnet.g@chu-toulouse.fr.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite. dominique.farge-bancel@aphp.fr 
      pugnet.g@chu-toulouse.fr.
FAU - Marjanovic, Zora
AU  - Marjanovic Z
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Deligny, Christophe
AU  - Deligny C
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Boussardon, Karine
AU  - Boussardon K
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Benzidia, Ilham
AU  - Benzidia I
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Puyade, Mathieu
AU  - Puyade M
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Lansiaux, Pauline
AU  - Lansiaux P
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Vandecasteele, Els
AU  - Vandecasteele E
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Smith, Vanessa
AU  - Smith V
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite.
FAU - Farge, Dominique
AU  - Farge D
AD  - From the Service de Medecine Interne, CHU Toulouse Purpan; Faculte de Medecine de 
      Toulouse, Toulouse; Hematologie clinique et therapie cellulaire, and Unite de 
      Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre 
      de reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, hopital Saint-Antoine; Universite Paris Diderot, Sorbonne Paris 
      Cite, Paris, France; Service de medecine interne, Centre national de reference 
      "Lupus, syndrome des antiphospholipides et autres maladies auto-immunes 
      systemiques rares," Hopital Pierre Zobda Quitman, CHU de Martinique, Fort de 
      France, Martinique; Service de Medecine Interne et Maladies Infectieuses, CHU de 
      Poitiers, Poitiers, France; Department of Cardiology, Department of Internal 
      Medicine, and Department of Rheumatology, Ghent University Hospital, Ghent, 
      Belgium. dominique.farge-bancel@aphp.fr pugnet.g@chu-toulouse.fr.
AD  - G. Pugnet, MD, PhD, Service de Medecine Interne, CHU Toulouse Purpan, and Faculte 
      de Medecine de Toulouse; Z. Marjanovic, MD, Hematologie clinique et therapie 
      cellulaire, AP-HP, hopital Saint-Antoine; C. Deligny, MD, PhD, Service de 
      medecine interne, Centre national de reference "Lupus, syndrome des 
      antiphospholipides et autres maladies auto-immunes systemiques rares," Hopital 
      Pierre Zobda Quitman, CHU de Martinique; K. Boussardon, MSc, Physiotherapist, 
      Unite de Medecine Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, 
      Centre de reference des maladies auto-immunes systemiques rares d'Ile-de-France, 
      Filiere (FAI2R), AP-HP, Hopital Saint-Louis; I. Benzidia, MD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; M. Puyade, MD, Service de Medecine Interne 
      et Maladies Infectieuses, CHU de Poitiers; P. Lansiaux, PhD, Unite de Medecine 
      Interne, Maladies Auto-immunes et Pathologie Vasculaire, UF 04, Centre de 
      reference des maladies auto-immunes systemiques rares d'Ile-de-France, Filiere 
      (FAI2R), AP-HP, Hopital Saint-Louis; E. Vandecasteele, MD, Department of 
      Cardiology, Ghent University Hospital; V. Smith, MD, PhD, Department of Internal 
      Medicine, Ghent University, and Department of Rheumatology, Ghent University 
      Hospital; D. Farge, MD, PhD, Unite de Medecine Interne, Maladies Auto-immunes et 
      Pathologie Vasculaire, UF 04, Centre de reference des maladies auto-immunes 
      systemiques rares d'Ile-de-France, Filiere (FAI2R), AP-HP, Hopital Saint-Louis, 
      Universite Paris Diderot, Sorbonne Paris Cite. dominique.farge-bancel@aphp.fr 
      pugnet.g@chu-toulouse.fr.
LA  - eng
PT  - Journal Article
DEP - 20180701
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
SB  - IM
MH  - Adult
MH  - Disability Evaluation
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Scleroderma, Systemic/mortality/*physiopathology
MH  - Survival Rate
MH  - *Walk Test
MH  - Walking/*physiology
OTO - NOTNLM
OT  - REPRODUCIBILITY OF RESULTS
OT  - SCLERODERMA
OT  - SURVIVAL ANALYSIS
OT  - SYSTEMIC SCLEROSIS
OT  - WALK TEST
EDAT- 2018/07/03 06:00
MHDA- 2019/11/15 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/04/06 00:00 [accepted]
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - jrheum.170994 [pii]
AID - 10.3899/jrheum.170994 [doi]
PST - ppublish
SO  - J Rheumatol. 2018 Aug;45(9):1273-1280. doi: 10.3899/jrheum.170994. Epub 2018 Jul 
      1.