PMID- 29962070
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20200613
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 39
IP  - 11
DP  - 2018 Nov
TI  - Default-mode network dynamics are restricted during high speed discrimination in 
      healthy aging: Associations with neurocognitive status and simulated driving 
      behavior.
PG  - 4196-4212
LID - 10.1002/hbm.24240 [doi]
AB  - Numerous daily tasks, including car driving, require fine visuospatial tuning. 
      One such visuospatial ability, speed discrimination, declines with aging but its 
      neural underpinnings remain unknown. In this study, we use fMRI to explore the 
      effect of aging during a high speed discrimination task and its neural 
      underpinnings, along with a complete neuropsychological assessment and a 
      simulated driving evaluation in order to examine how they interact with each 
      other through a multivariate regression approach. Beyond confirming that high 
      speed discrimination performance is diminished in the elderly, we found that this 
      deficit might be partly due to a lack of modulation in the activity and 
      connectivity of the default mode network (DMN) in this age group, as well as an 
      over-recruitment of frontoparietal and cerebellar regions, possibly as a 
      compensatory mechanism. In addition, younger adults tended to drive at faster 
      speeds, a behavior that was associated to adequate DMN dynamics and executive 
      functioning, an effect that seems to be lost in the elderly. In summary, these 
      results reveal how age-related declines in fine visuospatial abilities, such as 
      high speed discrimination, were distinctly mediated by DMN functioning, a 
      mechanism also associated to speeding behavior in a driving simulator.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Eudave, Luis
AU  - Eudave L
AUID- ORCID: 0000-0002-3490-0723
AD  - Neuroimaging Laboratory, Division of Neurosciences, Centre for Applied Medical 
      Research (CIMA), University of Navarra, Pamplona, 31008, Spain.
FAU - Martinez, Martin
AU  - Martinez M
AUID- ORCID: 0000-0002-3053-7920
AD  - Neuroimaging Laboratory, Division of Neurosciences, Centre for Applied Medical 
      Research (CIMA), University of Navarra, Pamplona, 31008, Spain.
FAU - Luis, Elkin O
AU  - Luis EO
AUID- ORCID: 0000-0002-7981-1177
AD  - Neuroimaging Laboratory, Division of Neurosciences, Centre for Applied Medical 
      Research (CIMA), University of Navarra, Pamplona, 31008, Spain.
AD  - School of Education and Psychology, University of Navarra, Pamplona, Spain.
FAU - Pastor, Maria A
AU  - Pastor MA
AUID- ORCID: 0000-0003-2404-9346
AD  - Neuroimaging Laboratory, Division of Neurosciences, Centre for Applied Medical 
      Research (CIMA), University of Navarra, Pamplona, 31008, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180701
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Automobile Driving/psychology
MH  - Brain/diagnostic imaging/*physiology
MH  - Brain Mapping
MH  - Computer Simulation
MH  - Discrimination, Psychological/*physiology
MH  - Female
MH  - Healthy Aging/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Motion Perception/*physiology
MH  - Neural Pathways/diagnostic imaging/physiology
MH  - Time Factors
PMC - PMC6866270
OTO - NOTNLM
OT  - aging
OT  - default mode network
OT  - driving simulator
OT  - elderly
OT  - fMRI
OT  - functional connectivity
OT  - high speed discrimination
OT  - lasso
COIS- The authors declare no conflict of interest.
EDAT- 2018/07/03 06:00
MHDA- 2019/06/14 06:00
PMCR- 2018/07/01
CRDT- 2018/07/03 06:00
PHST- 2017/12/22 00:00 [received]
PHST- 2018/04/12 00:00 [revised]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - HBM24240 [pii]
AID - 10.1002/hbm.24240 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2018 Nov;39(11):4196-4212. doi: 10.1002/hbm.24240. Epub 2018 Jul 
      1.