PMID- 29962073
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 35
IP  - 10
DP  - 2018 Oct
TI  - Cardiac shock wave therapy improves myocardial perfusion and preserves left 
      ventricular mechanics in patients with refractory angina: A study with speckle 
      tracking echocardiography.
PG  - 1564-1570
LID - 10.1111/echo.14054 [doi]
AB  - BACKGROUND: Cardiac shockwave therapy (CSWT) is a new potential option for the 
      treatment of patients with chronic coronary disease and refractory angina (RA). 
      We aimed to study the effects of CSWT on left ventricular myocardial perfusion 
      and mechanics in patients with RA. METHOD: We prospectively studied 19 patients 
      who underwent CSWT. Left ventricular mechanics were evaluated by speckle tracking 
      echocardiography (STE), and myocardial perfusion by single-photon emission 
      computed tomography, using stress/rest-Technetium-99 m Sestamibi, for 
      determination of summed stress score (SSS). Canadian Cardiac Society (CCS), New 
      York Heart Association (NYHA), and quality of life by Seattle Angina 
      Questionnaire (SAQ) were assessed at baseline and 6 months after therapy. 
      RESULTS: CSWT therapy was applied without major side effects. At baseline, 18 
      patients (94.7%) had CCS class III or IV, and after CSWT there was reduction to 3 
      (15.8%), P = .0001, associated with improvement in SAQ (38.5%; P < .001). 
      Thirteen (68.4%) had class NYHA III or IV before treatment, with significant 
      reduction to 7 (36.8%); P = .014. No change was observed in the global SSS from 
      baseline to 6-month follow-up (15.33 +/- 8.60 vs 16.60 +/- 8.06; P = .157). However, 
      there was a significant reduction in the average SSS of the treated ischemic 
      segments (2.1 +/- 0.87 pre vs 1.6 +/- 1.19 post CSWT; P = .024). Global longitudinal 
      strain by STE remained unaltered (-13.03 +/- 8.96 pre vs -15.88 +/- 3.43 6-month post 
      CSWT; P = .256). CONCLUSION: CSWT is a safe procedure for the treatment of 
      patients with RA that results in better quality of life, improvement in 
      myocardial perfusion of the treated segments with preservation of left 
      ventricular mechanics.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Duque, Anderson S
AU  - Duque AS
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Ceccon, Conrado L
AU  - Ceccon CL
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Mathias, Wilson Jr
AU  - Mathias W Jr
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Fleury Medicine and Health, Sao Paulo, Brazil.
FAU - Majesky, Joana Diniz
AU  - Majesky JD
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Gowdak, Luis H
AU  - Gowdak LH
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Sbano, Joao C N
AU  - Sbano JCN
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Fleury Medicine and Health, Sao Paulo, Brazil.
FAU - Cesar, Luis Antonio Machado
AU  - Cesar LAM
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Abduch, Maria Cristina
AU  - Abduch MC
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Lima, Marcio S M
AU  - Lima MSM
AUID- ORCID: 0000-0001-6110-2500
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Fleury Medicine and Health, Sao Paulo, Brazil.
FAU - Dourado, Paulo M M
AU  - Dourado PMM
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Cruz, Cecilia B B V
AU  - Cruz CBBV
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Fleury Medicine and Health, Sao Paulo, Brazil.
FAU - Tsutsui, Jeane M
AU  - Tsutsui JM
AUID- ORCID: 0000-0003-2449-0764
AD  - Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
AD  - Fleury Medicine and Health, Sao Paulo, Brazil.
LA  - eng
GR  - FAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/International
PT  - Journal Article
DEP - 20180701
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
RN  - 0 (Radiopharmaceuticals)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Angina Pectoris/complications/physiopathology/*therapy
MH  - Echocardiography/*methods
MH  - Extracorporeal Shockwave Therapy/*methods
MH  - Female
MH  - Heart/diagnostic imaging/*physiology
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiopharmaceuticals
MH  - Technetium Tc 99m Sestamibi
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/complications/physiopathology/*therapy
OTO - NOTNLM
OT  - left ventricular mechanics
OT  - myocardial perfusion
OT  - refractory angina
OT  - speckle tracking echocardiography
EDAT- 2018/07/03 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - 10.1111/echo.14054 [doi]
PST - ppublish
SO  - Echocardiography. 2018 Oct;35(10):1564-1570. doi: 10.1111/echo.14054. Epub 2018 
      Jul 1.