PMID- 29962322
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 22
IP  - 1
DP  - 2019 Feb
TI  - The Effects of Light and Moderate Intensity Exercise on the Femoral Bone and 
      Cerebellum of d-Galactose-Exposed Rats.
PG  - 20-30
LID - 10.1089/rej.2018.2050 [doi]
AB  - Aging causes the degeneration of organs of the locomotor system, including the 
      cerebellum and bones. Exercise may reverse this deterioration. d-galactose has 
      been frequently used in rodents to accelerate aging. The present study aimed at 
      investigating the effects of exercise on cerebellar and serum growth factors, 
      motor activity, and the number of bone cells of the femoral head of 
      d-galactose-treated rats. Twenty-four male Wistar rats were divided randomly into 
      four groups, that is, three treated groups injected with 300 mg/(mL.kg) body 
      weight (bw) d-galactose solution daily for 4 weeks, and a control group injected 
      with normal saline. Following the 4-week administration of d-galactose solution, 
      two of the treated groups performed light- (45% VO(2)max) and moderate- (55% 
      VO(2)max) intensity exercise, by running on a treadmill 4 x a week for 4 weeks. 
      Locomotor activity was examined in rotarod and open field tests. The cerebellar 
      and serum Insulin-like Growth Factor 1 (IGF-1) and Brain-Derived Neurotrophic 
      Factor (BDNF) levels were measured using enzyme-linked immunosorbent assay 
      (ELISA). The number of osteoblasts and osteoclasts of femoral head was estimated 
      using unbiased stereological methods. It was found that the number of osteoclasts 
      was higher in the d-galactose-treated group than the normal control and 
      moderate-intensity exercise groups. No significant difference between groups was 
      found in the rotarod and open field test performance, IGF-1 and BDNF levels, as 
      well as number of osteoblasts. In conclusion, a 4-week administration of 
      high-dosed-galactose caused the increase of the number of osteoclasts. A 
      subsequent 4-week moderate-intensity exercise reversed this increase to the 
      normal level.
FAU - Partadiredja, Ginus
AU  - Partadiredja G
AD  - 1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Karima, Nisa
AU  - Karima N
AD  - 1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
AD  - 2 Department of Biochemistry, Molecular Biology, and Physiology, Faculty of 
      Medicine, Universitas Lampung, Bandar Lampung, Indonesia.
FAU - Utami, Kurnia Putri
AU  - Utami KP
AD  - 1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
AD  - 3 Department of Physiotherapy, Faculty of Health Sciences, Universitas 
      Muhammadiyah Malang, Malang, Indonesia.
FAU - Agustiningsih, Denny
AU  - Agustiningsih D
AD  - 1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
FAU - Sofro, Zaenal Muttaqien
AU  - Sofro ZM
AD  - 1 Department of Physiology, Faculty of Medicine, Public Health, and Nursing, 
      Universitas Gadjah Mada, Yogyakarta, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20180823
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Animals
MH  - Bone and Bones/*cytology/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebellum/*cytology/drug effects/physiology
MH  - Femur/*cytology/drug effects/physiology
MH  - Galactose/*pharmacology
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Male
MH  - Motor Activity
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - -galactose
OT  - exercise
OT  - growth factor
OT  - osteoblast
OT  - osteoclast
EDAT- 2018/07/03 06:00
MHDA- 2019/03/14 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - 10.1089/rej.2018.2050 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2019 Feb;22(1):20-30. doi: 10.1089/rej.2018.2050. Epub 2018 Aug 
      23.