PMID- 29962653
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 0300-1652 (Print)
IS  - 2229-774X (Electronic)
IS  - 0300-1652 (Linking)
VI  - 58
IP  - 3
DP  - 2017 May-Jun
TI  - Determinants of Crystalluria among Type 2 Diabetes Patients; A Case-Control Study 
      of the Agona West Municipality, Ghana.
PG  - 114-118
LID - 10.4103/nmj.NMJ_121_16 [doi]
AB  - BACKGROUND/AIM: Type 2 diabetes mellitus (T2DM) has been implicated as a risk 
      factor for nephrolithiasis. The aim of this study was to determine the prevalence 
      and types of crystalluria among individuals with T2DM. It further sought to 
      identify associated risks, which could influence crystalluria. METHODS: A 
      case-control study with random sampling of 165 diabetes patients (cases) and 40 
      healthy non-diabetics (controls) was conducted from December 2012 to May 2013 at 
      the Agona Swedru Municipal Hospital, Ghana. Sociodemographic and anthropometric 
      data were obtained from the participants. Blood and urine samples were collected 
      for the estimation of blood glucose (fasting) and urinalysis for the presence of 
      crystals, respectively (light microscopy). RESULTS: Overall frequency of 
      crystalluria was 18.0%. The prevalence of urine crystals in diabetics (17.5%) was 
      more than that in non-diabetics (5.0%). Types of crystals found in the T2DM 
      patients by prevalence were calcium oxalate (12.7%), uric acid (3.6%), and 
      tyrosine (1.2%). Mean age, body mass index, systolic blood pressure, and fasting 
      blood glucose (FBG) were higher among case participants than in controls (P < 
      0.001; P < 0.001; P = 0.018; P < 0.001). Case participants had a lower urine pH 
      than the controls (P < 0.001). Crystalluria was positively correlated with FBG (P 
      = 0.002) and negatively with urine pH (P = 0.108). On multivariate analysis, FBG 
      was independently associated with crystalluria (P = 0.002), after adjustment for 
      other factors. CONCLUSION: Crystalluria is common in diabetes patients. Acidic 
      urine pH is mostly seen in T2DM and may be a predisposing factor to crystalluria. 
      Good glycemic control may be a helpful in reducing the occurrence of crystalluria 
      among T2DM.
FAU - Ephraim, Richard Kobina Dadzie
AU  - Ephraim RKD
AD  - Department of Medical Laboratory Technology, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast, Ghana.
FAU - Anoff, Kwaku Addo
AU  - Anoff KA
AD  - Department of Medical Laboratory Technology, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast, Ghana.
FAU - Brenyah, Ruth C
AU  - Brenyah RC
AD  - Department of Clinical Microbiology, School of Medical Sciences, KNUST, Kumasi, 
      Ghana.
FAU - Osakunor, Derick Nii Mensah
AU  - Osakunor DNM
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
FAU - Sakyi, Samuel Asamoah
AU  - Sakyi SA
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
FAU - Osei-Yeboah, James
AU  - Osei-Yeboah J
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
FAU - Anto, Enoch Odame
AU  - Anto EO
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC6009140
OTO - NOTNLM
OT  - Crystalluria
OT  - prevalence
OT  - type 2 diabetes
COIS- There are no conflicts of interest.
EDAT- 2017/05/01 00:00
MHDA- 2017/05/01 00:01
PMCR- 2017/05/01
CRDT- 2018/07/03 06:00
PHST- 2018/07/03 06:00 [entrez]
PHST- 2017/05/01 00:00 [pubmed]
PHST- 2017/05/01 00:01 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - NMJ-58-114 [pii]
AID - 10.4103/nmj.NMJ_121_16 [doi]
PST - ppublish
SO  - Niger Med J. 2017 May-Jun;58(3):114-118. doi: 10.4103/nmj.NMJ_121_16.