PMID- 29964172
OWN - NLM
STAT- MEDLINE
DCOM- 20181115
LR  - 20181115
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 548
IP  - 1
DP  - 2018 Sep 5
TI  - Exploring the role of polymeric conjugates toward anti-cancer drug delivery: 
      Current trends and future projections.
PG  - 500-514
LID - S0378-5173(18)30459-9 [pii]
LID - 10.1016/j.ijpharm.2018.06.060 [doi]
AB  - Utilizing the diverse features of biocompatible polymers to target drugs into the 
      tumor/s has been a research hotspot since last decade. Such polymeric conjugates 
      of anti-cancer drugs have proven their potential in providing sustained release 
      of drugs with reduced systemic toxicity and improved tumor retention. Polymers 
      like polyethylene glycol (PEG), N-(2-Hydroxypropyl) methacrylamide (HPMA), 
      Polylactic-co-glycolic acid (PLGA), Polyamidoamine (PAMAM), and others remain 
      exploited for their specific as well as shared characteristics in the rational 
      delivery of anti-cancer agents. Variable nano size, attachment with 
      tumor-specific proteins, responsiveness to stimuli and ability to deliver a wide 
      range of molecules like drugs, antibodies and peptides are some of the 
      achievements of polymeric nano-conjugates so far. Many such conjugates have shown 
      potential clinically which has attracted the researchers and promoted further 
      advancements of the technique. Apart from achievements the polymeric conjugates 
      suffer from shortcomings like poor drug loading and chances of potential 
      chronic-systemic toxicities. The review highlights key findings of research in 
      recent time and advancements taking place in the field of polymeric conjugates of 
      anti-cancer drugs along with the limitations. We have also emphasized on newer 
      and relatively less explored applications of tumor-targeted polymeric conjugates 
      which can add new dimensions to this technique.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Khan, Junaid
AU  - Khan J
AD  - Department of Pharmacy, Sarguja University, Ambikapur, Chhattisgarh 497001, 
      India.
FAU - Alexander, Amit
AU  - Alexander A
AD  - Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh 
      490024, India.
FAU - Ajazuddin
AU  - Ajazuddin
AD  - Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chhattisgarh 
      490024, India.
FAU - Saraf, Swarnlata
AU  - Saraf S
AD  - University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 
      Chhattisgarh 492010, India.
FAU - Saraf, Shailendra
AU  - Saraf S
AD  - University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 
      Chhattisgarh 492010, India; Durg University, Govt. Vasudev Vaman Patankar Girls' 
      P.G. College Campus, Raipur Naka, Durg, Chhattisgarh 491001, India. Electronic 
      address: drshailendrasaraf1010@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180628
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage/*chemistry
MH  - Drug Delivery Systems/*trends
MH  - Humans
MH  - Neoplasms/drug therapy
MH  - Polymers/administration & dosage/*chemistry
OTO - NOTNLM
OT  - Anticancer
OT  - Nanoparticles
OT  - Polyethylene glycol
OT  - Polymeric conjugates
OT  - Polymers
EDAT- 2018/07/03 06:00
MHDA- 2018/11/16 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/06/27 00:00 [revised]
PHST- 2018/06/27 00:00 [accepted]
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2018/11/16 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - S0378-5173(18)30459-9 [pii]
AID - 10.1016/j.ijpharm.2018.06.060 [doi]
PST - ppublish
SO  - Int J Pharm. 2018 Sep 5;548(1):500-514. doi: 10.1016/j.ijpharm.2018.06.060. Epub 
      2018 Jun 28.