PMID- 29965887
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
VI  - 15
IP  - 2
DP  - 2021 Mar 1
TI  - MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL 
      NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA 
      ELASTICUM.
PG  - 155-162
LID - 10.1097/ICB.0000000000000759 [doi]
AB  - PURPOSE: To describe a case of focal choroidal excavation (FCE) complicated with 
      Type-2 choroidal neovascularization (CNV) in a patient with angioid streaks 
      secondary to pseudoxanthoma elasticum before and after treatment with 
      bevacizumab. METHODS: Fundus photography, fundus autofluorescence, fluorescein 
      angiography, indocyanine green angiography, spectral-domain optical coherence 
      tomography (SD-OCT) and SD-OCT angiography were performed in a 60-year-old white 
      woman with angioid streaks and bilateral FCE. Spectral domain OCT images were 
      taken before and after three-monthly intravitreal injections of bevacizumab. 
      Histopathological analysis of the dermis established the diagnosis of 
      pseudoxanthoma elasticum. RESULTS: Multimodal imaging revealed bilateral FCE and 
      CNV. Spectral domain OCT diagnosed bilateral FCE and Type-1 and Type-2 CNV in the 
      right eye, and irregular vascular network, along macular streak, in both eyes, 
      which were not observed on fluorescein neither on indocyanine green angiography, 
      but only on SD-OCT angiography. Patient presented good anatomical and functional 
      response to intravitreal injections of bevacizumab. CONCLUSION: Focal choroidal 
      excavation is a rare condition detected mainly by SD-OCT, which may be associated 
      with angioid streaks secondary to pseudoxanthoma elasticum and complicated by 
      CNV. Multimodal imaging is important for diagnosis and follow-up of such 
      patients, even in the absence of signs of CNV, and anatomical and functional 
      response to anti-vascular endothelial growth factor therapy is good.
FAU - Ferreira, Bruno Fortaleza de Aquino
AU  - Ferreira BFA
AD  - Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Preti, Rony Carlos
AU  - Preti RC
FAU - Schmidt, Marina Brandao
AU  - Schmidt MB
FAU - Zacharias, Leandro Cabral
AU  - Zacharias LC
FAU - Takahashi, Walter Yukihiko
AU  - Takahashi WY
FAU - Monteiro, Mario Luiz Ribeiro
AU  - Monteiro MLR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Angioid Streaks/*complications/diagnosis
MH  - Choroid/*pathology
MH  - Choroidal Neovascularization/diagnosis/*etiology
MH  - Coloring Agents/administration & dosage
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green/administration & dosage
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Pseudoxanthoma Elasticum/*complications/diagnosis
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2018/07/03 06:00
MHDA- 2023/02/25 06:00
CRDT- 2018/07/03 06:00
PHST- 2018/07/03 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2018/07/03 06:00 [entrez]
AID - 01271216-202103000-00015 [pii]
AID - 10.1097/ICB.0000000000000759 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2021 Mar 1;15(2):155-162. doi: 
      10.1097/ICB.0000000000000759.