PMID- 29966287 OWN - NLM STAT- MEDLINE DCOM- 20181023 LR - 20211204 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 10 IP - 7 DP - 2018 Jun 29 TI - A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults. LID - 10.3390/nu10070849 [doi] LID - 849 AB - Previously thought to be mainly a disorder of childhood and early adult life, coeliac disease (CeD) is increasingly diagnosed in older adults. This may be important given the association between CeD and osteoporosis. The primary aim of this study was to determine the seroprevalence of undiagnosed CeD (‘at-risk serology’) in an older Australian community and relate this to a diagnosis of osteoporosis and fractures during a follow-up period of 12 years. We included participants from the Hunter Community Study (2004(-)2007) aged 55(-)85, who had anti-tissue transglutaminase (tTG) titres, human leukocyte antigen (HLA) genotypes, and bone mineral density measurements at baseline. Follow-up data included subsequent diagnosis of CeD and fractures using hospital information. ‘At-risk’ serology was defined as both tTG and HLA positivity. Complete results were obtained from 2122 patients. The prevalence of ‘at-risk’ serology was 5%. At baseline, 3.4% fulfilled criteria for a diagnosis of osteoporosis. During a mean of 9.7 years of follow-up, 7.4% of the cohort suffered at least one fracture and 0.7% were subsequently diagnosed with CeD. At-risk serology was significantly associated with osteoporosis in a multivariate model (odds ratio 2.83, 95% confidence interval 1.29(-)6.22); there was insufficient power to look at the outcome of fractures. The results of this study demonstrate that at-risk CeD serology was significantly associated with concurrent osteoporosis but not future fractures. Most individuals with a serological diagnosis of CeD were not diagnosed with CeD during the follow-up period according to medical records. Coeliac disease likely remains under-diagnosed. FAU - Potter, Michael D E AU - Potter MDE AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. michael.potter@newcastle.edu.au. AD - Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. michael.potter@newcastle.edu.au. AD - Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. michael.potter@newcastle.edu.au. FAU - Walker, Marjorie M AU - Walker MM AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. marjorie.walker@newcastle.edu.au. AD - Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. marjorie.walker@newcastle.edu.au. FAU - Hancock, Stephen AU - Hancock S AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Stephen.hancock@newcastle.edu.au. FAU - Holliday, Elizabeth AU - Holliday E AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. liz.holliday@newcastle.edu.au. FAU - Brogan, Gregory AU - Brogan G AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. gregory.brogan@hnehealth.nsw.gov.au. AD - Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. gregory.brogan@hnehealth.nsw.gov.au. FAU - Jones, Michael AU - Jones M AD - Department of Psychology, Macquarie University, Sydney 2109, Australia. mike.jones@mq.edu.au. FAU - McEvoy, Mark AU - McEvoy M AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Mark.McEvoy@newcastle.edu.au. FAU - Boyle, Michael AU - Boyle M AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. Michael.boyle@hnehealth.nsw.gov.au. AD - Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. Michael.boyle@hnehealth.nsw.gov.au. FAU - Talley, Nicholas J AU - Talley NJ AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. nicholas.talley@newcastle.edu.au. AD - Australian Gastrointestinal Research Alliance (AGIRA), Newcastle 2305, Australia. nicholas.talley@newcastle.edu.au. AD - Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. nicholas.talley@newcastle.edu.au. FAU - Attia, John AU - Attia J AUID- ORCID: 0000-0001-9800-1308 AD - Faculty of Health and Medicine, University of Newcastle, Level 3 East, HMRI Building, Lookout Road, New Lambton Heights 2305, Australia. john.attia@newcastle.edu.au. AD - Department of Medicine, John Hunter Hospital, Newcastle 2305, Australia. john.attia@newcastle.edu.au. LA - eng PT - Journal Article DEP - 20180629 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Autoantibodies) RN - 0 (HLA Antigens) RN - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2) RN - EC 2.3.2.13 (Transglutaminases) RN - EC 3.6.1.- (GTP-Binding Proteins) SB - IM MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Autoantibodies/*blood MH - Bone Density MH - Celiac Disease/*blood/diagnosis/*epidemiology/immunology MH - Female MH - GTP-Binding Proteins/*immunology MH - HLA Antigens/immunology MH - Humans MH - Male MH - Middle Aged MH - New South Wales/epidemiology MH - Osteoporosis/diagnosis/*epidemiology/physiopathology MH - Osteoporotic Fractures/epidemiology MH - Prevalence MH - Protein Glutamine gamma Glutamyltransferase 2 MH - Risk Factors MH - Seroepidemiologic Studies MH - Serologic Tests MH - Time Factors MH - Transglutaminases/*immunology PMC - PMC6073845 OTO - NOTNLM OT - coeliac disease OT - fractures OT - osteoporosis COIS- The authors declare no conflicts of interest. EDAT- 2018/07/04 06:00 MHDA- 2018/10/24 06:00 PMCR- 2018/07/01 CRDT- 2018/07/04 06:00 PHST- 2018/05/30 00:00 [received] PHST- 2018/06/25 00:00 [revised] PHST- 2018/06/26 00:00 [accepted] PHST- 2018/07/04 06:00 [entrez] PHST- 2018/07/04 06:00 [pubmed] PHST- 2018/10/24 06:00 [medline] PHST- 2018/07/01 00:00 [pmc-release] AID - nu10070849 [pii] AID - nutrients-10-00849 [pii] AID - 10.3390/nu10070849 [doi] PST - epublish SO - Nutrients. 2018 Jun 29;10(7):849. doi: 10.3390/nu10070849.