PMID- 29966339
OWN - NLM
STAT- MEDLINE
DCOM- 20190424
LR  - 20230926
IS  - 1424-8220 (Electronic)
IS  - 1424-8220 (Linking)
VI  - 18
IP  - 7
DP  - 2018 Jun 30
TI  - Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording 
      and Sub-Millisecond Processing of Biosignals.
LID - 10.3390/s18072099 [doi]
LID - 2099
AB  - Enhanced understanding and control of electrophysiology mechanisms are 
      increasingly being hailed as key knowledge in the fields of modern biology and 
      medicine. As more and more excitable cell mechanics are being investigated and 
      exploited, the need for flexible electrophysiology setups becomes apparent. With 
      that aim, we designed Multimed, which is a versatile hardware platform for the 
      real-time recording and processing of biosignals. Digital processing in Multimed 
      is an arrangement of generic processing units from a custom library. These can 
      freely be rearranged to match the needs of the application. Embedded onto a Field 
      Programmable Gate Array (FPGA), these modules utilize full-hardware signal 
      processing to lower processing latency. It achieves constant latency, and 
      sub-millisecond processing and decision-making on 64 channels. The FPGA core 
      processing unit makes Multimed suitable as either a reconfigurable 
      electrophysiology system or a prototyping platform for VLSI implantable medical 
      devices. It is specifically designed for open- and closed-loop experiments and 
      provides consistent feedback rules, well within biological microseconds 
      timeframes. This paper presents the specifications and architecture of the 
      Multimed system, then details the biosignal processing algorithms and their 
      digital implementation. Finally, three applications utilizing Multimed in 
      neuroscience and diabetes research are described. They demonstrate the 
      system’s configurability, its multi-channel, real-time processing, and its 
      feedback control capabilities.
FAU - Pirog, Antoine
AU  - Pirog A
AD  - Laboratoire de l'Integration du Materiau au Systeme (IMS), University of 
      Bordeaux, Bordeaux INP, CNRS UMR 5218, F-33400 Talence, France. 
      antoine.pirog@bordeaux-inp.fr.
FAU - Bornat, Yannick
AU  - Bornat Y
AUID- ORCID: 0000-0003-4758-7227
AD  - Laboratoire de l'Integration du Materiau au Systeme (IMS), University of 
      Bordeaux, Bordeaux INP, CNRS UMR 5218, F-33400 Talence, France. 
      yannick.bornat@ims-bordeaux.fr.
FAU - Perrier, Romain
AU  - Perrier R
AD  - Signalisation et physiopathologie cardiovasculaire, INSERM S-1180, University of 
      Paris Sud, F-92296 Chatenay-Malabry, France. romain.perrier@u-psud.fr.
FAU - Raoux, Matthieu
AU  - Raoux M
AD  - Institut de Chimie et Biologie des Membranes et des Nano-objets (CBMN), 
      University of Bordeaux, CNRS UMR 5248, F-33600 Pessac, France. 
      m.raoux@cbmn.u-bordeaux.fr.
FAU - Jaffredo, Manon
AU  - Jaffredo M
AD  - Institut de Chimie et Biologie des Membranes et des Nano-objets (CBMN), 
      University of Bordeaux, CNRS UMR 5248, F-33600 Pessac, France. 
      manon.jaffredo@u-bordeaux.fr.
FAU - Quotb, Adam
AU  - Quotb A
AD  - Laboratoire d'Analyse et d'Architecture des Systemes (LAAS), Federal University 
      of Toulouse Midi-Pyrenees, CNRS UMR 8001, F-31031 Toulouse, France. 
      adam.quotb@enseeiht.fr.
FAU - Lang, Jochen
AU  - Lang J
AUID- ORCID: 0000-0001-6847-5641
AD  - Institut de Chimie et Biologie des Membranes et des Nano-objets (CBMN), 
      University of Bordeaux, CNRS UMR 5248, F-33600 Pessac, France. 
      j.lang@cbmn.u-bordeaux.fr.
FAU - Lewis, Noelle
AU  - Lewis N
AD  - Laboratoire de l'Integration du Materiau au Systeme (IMS), University of 
      Bordeaux, Bordeaux INP, CNRS UMR 5218, F-33400 Talence, France. 
      noelle.lewis@ims-bordeaux.fr.
FAU - Renaud, Sylvie
AU  - Renaud S
AUID- ORCID: 0000-0001-5632-7991
AD  - Laboratoire de l'Integration du Materiau au Systeme (IMS), University of 
      Bordeaux, Bordeaux INP, CNRS UMR 5218, F-33400 Talence, France. 
      sylvie.renaud@ims-bordeaux.fr.
LA  - eng
PT  - Journal Article
DEP - 20180630
PL  - Switzerland
TA  - Sensors (Basel)
JT  - Sensors (Basel, Switzerland)
JID - 101204366
SB  - IM
MH  - Algorithms
MH  - Biomedical Research/*methods
MH  - Diabetes Mellitus
MH  - Electrophysiological Phenomena/*physiology
MH  - Feedback
MH  - Humans
MH  - Neurosciences/*methods
MH  - *Signal Processing, Computer-Assisted
MH  - Time Factors
PMC - PMC6069272
OTO - NOTNLM
OT  - FPGA
OT  - biosignal processing
OT  - electrophysiology
OT  - multi-application
OT  - multi-channel
OT  - neural recording
OT  - pancreatic islet recording
OT  - real-time
COIS- The authors declare no conflict of interest.
EDAT- 2018/07/04 06:00
MHDA- 2019/04/25 06:00
PMCR- 2018/07/01
CRDT- 2018/07/04 06:00
PHST- 2018/05/29 00:00 [received]
PHST- 2018/06/23 00:00 [revised]
PHST- 2018/06/27 00:00 [accepted]
PHST- 2018/07/04 06:00 [entrez]
PHST- 2018/07/04 06:00 [pubmed]
PHST- 2019/04/25 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - s18072099 [pii]
AID - sensors-18-02099 [pii]
AID - 10.3390/s18072099 [doi]
PST - epublish
SO  - Sensors (Basel). 2018 Jun 30;18(7):2099. doi: 10.3390/s18072099.