PMID- 29966363 OWN - NLM STAT- MEDLINE DCOM- 20181023 LR - 20240329 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 10 IP - 7 DP - 2018 Jun 30 TI - Neuroprotective Effects of Soy Isoflavones on Scopolamine-Induced Amnesia in Mice. LID - 10.3390/nu10070853 [doi] LID - 853 AB - In the recent years, interest in soybean as a neuroprotective nutrient in the management of Alzheimer’s disease (AD) has increased and soy isoflavones (SI), as kinds of soybean phytochemicals, are thought to be biologically active components that confer this beneficial effect against neurodegenerative diseases. However, the neuroprotective effect of SI is not well understood. Therefore, the present study (30 days) was conducted to investigate the neuroprotective effects of soy isoflavones (SI) on scopolamine (SCOP)-induced memory impairments in Institute of Cancer Research (ICR) mice (aged 4 weeks) and to elucidate its underlying mechanisms of action. SI (40 mg/kg) administration improved the cognitive performance of SCOP-treated mice in an object location recognition task and the Morris water maze test. SI (40 mg/kg) administration significantly enhanced cholinergic system function and suppressed oxidative stress levels in the hippocampus of SCOP-treated mice. Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus. Taken together, these results demonstrated that soy isoflavones exerted a significant neuroprotective effect on cognitive dysfunctions induced by scopolamine, suggesting that soy isoflavones could be a good candidate for possible treatment of neurodegenerative diseases, such as Alzheimer’s disease (AD). FAU - Lu, Cong AU - Lu C AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. lucong198912@126.com. AD - Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, China. lucong198912@126.com. FAU - Wang, Yan AU - Wang Y AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. wy198565@163.com. FAU - Wang, Donghui AU - Wang D AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. wangdonghui01@caas.cn. FAU - Zhang, Lijing AU - Zhang L AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. zhanglijingg@126.com. FAU - Lv, Jingwei AU - Lv J AD - Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, China. jwlv000@163.com. FAU - Jiang, Ning AU - Jiang N AD - Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, China. jiangning0603@163.com. FAU - Fan, Bei AU - Fan B AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. fanbei517@163.com. FAU - Liu, Xinmin AU - Liu X AD - Research Center for Pharmacology & Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100193, China. xmliu@implad.ac.cn. FAU - Wang, Fengzhong AU - Wang F AD - Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. wangfengzhong@sina.com. LA - eng PT - Journal Article DEP - 20180630 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Antioxidants) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Creb1 protein, mouse) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 0 (GPI-Linked Proteins) RN - 0 (Isoflavones) RN - 0 (Neuroprotective Agents) RN - DL48G20X8X (Scopolamine) RN - EC 2.3.1.6 (Choline O-Acetyltransferase) RN - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) RN - EC 3.1.1.7 (Acetylcholinesterase) RN - EC 3.1.1.7 (Ache protein, mouse) RN - N9YNS0M02X (Acetylcholine) SB - IM MH - Acetylcholine/metabolism MH - Acetylcholinesterase/metabolism MH - Amnesia/chemically induced/metabolism/*prevention & control/psychology MH - Animals MH - Antioxidants/pharmacology MH - Behavior, Animal/*drug effects MH - Brain-Derived Neurotrophic Factor/metabolism MH - Choline O-Acetyltransferase/metabolism MH - Cholinergic Neurons/drug effects/metabolism MH - Cognition/drug effects MH - Cyclic AMP Response Element-Binding Protein/metabolism MH - Disease Models, Animal MH - Dose-Response Relationship, Drug MH - Extracellular Signal-Regulated MAP Kinases/metabolism MH - GPI-Linked Proteins/metabolism MH - Hippocampus/*drug effects/metabolism/physiopathology MH - Isoflavones/isolation & purification/*pharmacology MH - Male MH - Maze Learning/drug effects MH - Memory/*drug effects MH - Mice, Inbred ICR MH - Neuroprotective Agents/isolation & purification/*pharmacology MH - Oxidative Stress/drug effects MH - Phosphorylation MH - *Scopolamine MH - *Glycine max/chemistry MH - Time Factors PMC - PMC6073222 OTO - NOTNLM OT - ERK/CREB/BDNF pathway OT - cholinergic system function OT - learning and memory OT - oxidative stress OT - scopolamine OT - soy isoflavones COIS- The authors declare no conflict of interest. EDAT- 2018/07/04 06:00 MHDA- 2018/10/24 06:00 PMCR- 2018/07/01 CRDT- 2018/07/04 06:00 PHST- 2018/06/06 00:00 [received] PHST- 2018/06/26 00:00 [revised] PHST- 2018/06/28 00:00 [accepted] PHST- 2018/07/04 06:00 [entrez] PHST- 2018/07/04 06:00 [pubmed] PHST- 2018/10/24 06:00 [medline] PHST- 2018/07/01 00:00 [pmc-release] AID - nu10070853 [pii] AID - nutrients-10-00853 [pii] AID - 10.3390/nu10070853 [doi] PST - epublish SO - Nutrients. 2018 Jun 30;10(7):853. doi: 10.3390/nu10070853.