PMID- 29967357
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jul 2
TI  - Phenotypes of Jackhammer esophagus in patients with typical symptoms of 
      gastroesophageal reflux disease responsive to proton pump inhibitors.
PG  - 9949
LID - 10.1038/s41598-018-27756-9 [doi]
LID - 9949
AB  - This trial was designed to assess the prevalence and characteristics of 
      Jackhammer esophagus (JE), a novel hypercontractile disorder associated with 
      progression to achalasia and limited outcomes following anti-reflux surgery in 
      patients with typical symptoms of GERD and responsiveness to proton pump 
      inhibitor (PPI) therapy. Consecutive patients, who were referred for surgical 
      therapy because of PPI responsive typical symptoms of GERD, were prospectively 
      assessed between January 2014 and May 2017. Patients diagnosed with JE 
      subsequently underwent rigorous clinical screening including 
      esophagogastroduodenoscopy (EGD), ambulatory pH impedance monitoring off PPI and 
      a PPI trial. Out of 2443 evaluated patients, 37 (1.5%) subjects with a median age 
      of 56.3 (51.6; 65) years were diagnosed with JE and left for final analysis. 
      Extensive testing resulted in 16 (43.2%) GERD positive patients and 5 (13.9%) 
      participants were observed to have an acid hypersensitive esophagus. There were 
      no clinical parameters that differentiated phenotypes of JE. The prevalence of JE 
      in patients with typical symptoms of GERD and response to PPI therapy is low. 
      True GERD was diagnosed in less than half of this selected cohort, indicating the 
      need for objective testing to stratify phenotypes of JE. (NCT03347903).
FAU - Kristo, Ivan
AU  - Kristo I
AUID- ORCID: 0000-0001-7999-1625
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Schwameis, Katrin
AU  - Schwameis K
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Maschke, Svenja
AU  - Maschke S
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Kainz, Alexander
AU  - Kainz A
AD  - Department of Internal Medicine III, Medical University of Vienna, Vienna, 
      Austria.
FAU - Rieder, Erwin
AU  - Rieder E
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Paireder, Matthias
AU  - Paireder M
AUID- ORCID: 0000-0001-7119-8454
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Jomrich, Gerd
AU  - Jomrich G
AUID- ORCID: 0000-0002-7294-4831
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria.
FAU - Schoppmann, Sebastian F
AU  - Schoppmann SF
AUID- ORCID: 0000-0002-1725-7086
AD  - Department of Surgery, Upper GI Research & Service, Medical University of Vienna, 
      Vienna, Austria. sebastian.schoppmann@meduniwien.ac.at.
LA  - eng
SI  - ClinicalTrials.gov/NCT03347903
PT  - Journal Article
PT  - Observational Study
DEP - 20180702
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Proton Pump Inhibitors)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Aged
MH  - Endoscopy, Digestive System
MH  - Esomeprazole/therapeutic use
MH  - Esophageal Motility Disorders/diagnosis/*drug therapy/epidemiology/*etiology
MH  - Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/drug therapy/etiology
MH  - Humans
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Prevalence
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Outcome
PMC - PMC6028385
COIS- The authors declare no competing interests.
EDAT- 2018/07/04 06:00
MHDA- 2019/10/24 06:00
PMCR- 2018/07/02
CRDT- 2018/07/04 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/06/05 00:00 [accepted]
PHST- 2018/07/04 06:00 [entrez]
PHST- 2018/07/04 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/07/02 00:00 [pmc-release]
AID - 10.1038/s41598-018-27756-9 [pii]
AID - 27756 [pii]
AID - 10.1038/s41598-018-27756-9 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jul 2;8(1):9949. doi: 10.1038/s41598-018-27756-9.