PMID- 29969046
OWN - NLM
STAT- MEDLINE
DCOM- 20191231
LR  - 20231213
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 60
IP  - 1
DP  - 2019 Jan
TI  - Clinical significance of HLA-E genotype and surface/soluble expression levels 
      between healthy individuals and patients with acute leukemia.
PG  - 208-215
LID - 10.1080/10428194.2018.1474521 [doi]
AB  - Human leukocyte antigen (HLA)-E is a nonclassical HLA molecule with limited 
      polymorphisms. Genotype frequency and expression of HLA-E were examined here for 
      the first time in acute leukemia patients and healthy controls. The frequency of 
      HLA-E*01:03/*01:03 individuals was significantly higher (p = .008, OR = 1.845), 
      while the frequency of HLA-E*01:01/*01:01 individuals was much lower in the 
      patient group (p = .002, OR = .363) than in control group. The surface expression 
      on HLA-E*01:03/*01:03 individuals was found to be significantly higher than on 
      HLA-E*01:01/*01:01 individuals in both of acute leukemia and control groups, but 
      no significant difference was observed between the corresponding genotypes in two 
      groups. However, the level of expression of soluble HLA-E is significantly higher 
      in patients than in the control group, but there was no genotype-specific 
      expression in either group. These findings indicate that soluble HLA-E secretion 
      and HLA-E*01:03/*01:03 genotype that brings higher surface expression might play 
      important roles in the mechanisms underlying tumor escape in acute leukemia.
FAU - Xu, Yun-Ping
AU  - Xu YP
AD  - a Immunogenetics Laboratory , Shenzhen Institute of Transfusion Medicine, 
      Shenzhen Blood Center , Shenzhen , China.
AD  - b Transplantation Immunology, Tissue Typing Laboratory , Maastricht University 
      Medical Center , Maastricht , The Netherlands.
FAU - Wieten, Lotte
AU  - Wieten L
AD  - b Transplantation Immunology, Tissue Typing Laboratory , Maastricht University 
      Medical Center , Maastricht , The Netherlands.
FAU - Wang, Song-Xing
AU  - Wang SX
AD  - a Immunogenetics Laboratory , Shenzhen Institute of Transfusion Medicine, 
      Shenzhen Blood Center , Shenzhen , China.
FAU - Cai, Yun
AU  - Cai Y
AD  - c Department of Hematopathology , Shenzhen Second People's Hospital , Shenzhen , 
      China.
FAU - Olieslagers, Timo
AU  - Olieslagers T
AD  - b Transplantation Immunology, Tissue Typing Laboratory , Maastricht University 
      Medical Center , Maastricht , The Netherlands.
FAU - Zhang, Li
AU  - Zhang L
AD  - a Immunogenetics Laboratory , Shenzhen Institute of Transfusion Medicine, 
      Shenzhen Blood Center , Shenzhen , China.
FAU - He, Liu-Mei
AU  - He LM
AD  - a Immunogenetics Laboratory , Shenzhen Institute of Transfusion Medicine, 
      Shenzhen Blood Center , Shenzhen , China.
FAU - Tilanus, Marce G J
AU  - Tilanus MGJ
AD  - b Transplantation Immunology, Tissue Typing Laboratory , Maastricht University 
      Medical Center , Maastricht , The Netherlands.
FAU - Hong, Wen-Xu
AU  - Hong WX
AUID- ORCID: 0000-0001-7602-4517
AD  - a Immunogenetics Laboratory , Shenzhen Institute of Transfusion Medicine, 
      Shenzhen Blood Center , Shenzhen , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180703
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Healthy Volunteers
MH  - Histocompatibility Antigens Class I/*genetics/immunology/metabolism
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Tumor Escape/*genetics
MH  - Young Adult
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - Acute leukemia
OT  - expression
OT  - human leukocyte antigen E molecule
OT  - polymorphism
EDAT- 2018/07/04 06:00
MHDA- 2020/01/01 06:00
CRDT- 2018/07/04 06:00
PHST- 2018/07/04 06:00 [pubmed]
PHST- 2020/01/01 06:00 [medline]
PHST- 2018/07/04 06:00 [entrez]
AID - 10.1080/10428194.2018.1474521 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2019 Jan;60(1):208-215. doi: 10.1080/10428194.2018.1474521. Epub 
      2018 Jul 3.