PMID- 29969645
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 142
DP  - 2018 Sep
TI  - Neural circuitry among connecting the hippocampus, prefrontal cortex and 
      basolateral amygdala in a mouse depression model: Associations correlations 
      between BDNF levels and BOLD - fMRI signals.
PG  - 107-115
LID - S0361-9230(18)30423-4 [pii]
LID - 10.1016/j.brainresbull.2018.06.019 [doi]
AB  - BACKGROUND: Depression is a heterogeneous disorder, but the exact neuronal 
      mechanisms causing the disease have not yet been discovered. METHODS/MATERIALS: 
      We have established a chronic unpredictable mild stress (CUMS) mouse model to 
      explore the blood oxygen level-dependent (BOLD) activity in the hippocampus, 
      prefrontal cortex (PFC), and basolateral amygdala (BLA) using amplitude of 
      low-frequency fluctuations (ALFF) in functional magnetic resonance imaging 
      (fMRI). We initially studied the relationship between brain-derived neurotrophic 
      factor (BDNF) expression and BOLD activity using BDNF(tm1Krj/J) mice. RESULTS: We 
      found that CUMS induced depressive-like behaviours and stimulated changes in 
      brain regions expressing a different BDNF level, which was decreased in the 
      hippocampus and PFC but increased in the BLA. In contrast, the BOLD activity was 
      elevated in the hippocampus and PFC but reduced in the BLA after CUMS exposure, 
      indicating that the BDNF level negatively correlated with the BOLD activity in 
      the WT CUMS-exposed mice. Moreover, the depressive-like behaviours and 
      region-specific BOLD activity in BDNF(tm1Krj/J) mice were consistent with those 
      in WT CUMS-exposed mice. CONCLUSION: We surmised that critical neural circuitry 
      connects the hippocampus, PFC and BLA in mice, which was regulated by BDNF to 
      protect against depression. These findings suggested a potential central role of 
      BDNF expression in functional changes in the brain.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Huang, Peng
AU  - Huang P
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China; Foshan Maternal and Child Health Research Institute, Affiliated 
      Hospital of Southern Medical University, Foshan, Guangdong, China.
FAU - Gao, Tingting
AU  - Gao T
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Dong, Zhaoyang
AU  - Dong Z
AD  - School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou, 
      Guangdong, China.
FAU - Zhou, Chuying
AU  - Zhou C
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Lai, Yuling
AU  - Lai Y
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Pan, Ting
AU  - Pan T
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Liu, Yuan
AU  - Liu Y
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Zhao, Xiaoshan
AU  - Zhao X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Sun, Xuegang
AU  - Sun X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
FAU - Hua, Heyu
AU  - Hua H
AD  - School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, 
      China.
FAU - Wen, Ge
AU  - Wen G
AD  - Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 
      Electronic address: 1113470826@qq.com.
FAU - Gao, Lei
AU  - Gao L
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China. Electronic address: raygaolei@smu.edu.cn.
FAU - Lv, Zhiping
AU  - Lv Z
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China. Electronic address: lzp48241@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180630
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - S88TT14065 (Oxygen)
EIN - Brain Res Bull. 2019 Nov;153:350. PMID: 31699272
MH  - Animals
MH  - Brain/*diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebrovascular Circulation/physiology
MH  - Depressive Disorder/*diagnostic imaging/*physiopathology
MH  - Disease Models, Animal
MH  - Gene Expression
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Neurogenesis/physiology
MH  - Oxygen/blood
MH  - Random Allocation
MH  - Stress, Psychological/diagnostic imaging/physiopathology
OTO - NOTNLM
OT  - BDNF
OT  - BLA
OT  - Depression
OT  - Hippocampus
OT  - PFC
OT  - fMRI
EDAT- 2018/07/04 06:00
MHDA- 2019/07/28 06:00
CRDT- 2018/07/04 06:00
PHST- 2018/06/05 00:00 [received]
PHST- 2018/06/21 00:00 [revised]
PHST- 2018/06/28 00:00 [accepted]
PHST- 2018/07/04 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2018/07/04 06:00 [entrez]
AID - S0361-9230(18)30423-4 [pii]
AID - 10.1016/j.brainresbull.2018.06.019 [doi]
PST - ppublish
SO  - Brain Res Bull. 2018 Sep;142:107-115. doi: 10.1016/j.brainresbull.2018.06.019. 
      Epub 2018 Jun 30.