PMID- 29970710
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20220318
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 14
IP  - Supplement
DP  - 2018 Jun
TI  - Imbalance of T-helper 1/T-helper 2 cytokines and impaired glucose tolerance among 
      patient with acute coronary syndrome.
PG  - S480-S485
LID - 10.4103/0973-1482.194346 [doi]
AB  - PURPOSE: The balance between T helper (Th) cells Th1- and Th2-related cytokines 
      plays a key role in the clinical process of acute coronary syndrome (ACS) and 
      type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). The 
      objective of this study was to assess the status of Th1/Th2 cytokines in patients 
      with ACS and T2D or IGT. METHODS: A total of 201 ACS patients were enrolled in 
      the study. All ACS patients were divided into three groups: Group I-patients with 
      normal glucose tolerance (NGT), Group II-patients with IGT and Group III-patients 
      with T2D. We measured circulating Th1/Th2-type cytokines (interleukin [IL]-4, 
      IL-13, interferon-gamma [IFN-gamma], and tumor-necrosis factor-alpha [TNF-alpha]) using 
      enzyme-linked immunosorbent assay and calculated the ratio of Th1/Th2. RESULTS: 
      Significant elevations in serum levels of IL-4, IL-13, IFN-gamma, and TNF-alpha were 
      found in ACS-T2D and ACS-IGT groups compared to that in both ACS-NGT group and 
      healthy individuals. Higher serum levels of IL-4, IL-13, and TNF-alpha were found in 
      ACS-NGT group than that in the control group. Furthermore, IL-4 and IFN-gamma 
      concentrations were significantly higher in ACS-T2D patients than in ACS-IGT 
      patients. IFN-gamma/IL-4, IFN-gamma/IL-13, and TNF-alpha/IL-4 ratios as markers of Th1/Th2 
      ratio were significantly higher for the ACS-T2D group and ACS-IGT group as 
      compared to that in the ACS-NGT group and control group (P < 0.05). CONCLUSION: 
      Shifts in the balance of Th1/Th2 toward a predominance of Th1 may represent more 
      severe inflammatory status in ACS patients with type T2D or IGT.
FAU - Zhao, Shao-Li
AU  - Zhao SL
AD  - Department of Endocrinology, Third Xiangya Hospital, Central South University, 
      Changsha 410013, Hunan Province, China.
FAU - Mo, Zhao-Hui
AU  - Mo ZH
AD  - Department of Endocrinology, Third Xiangya Hospital, Central South University, 
      Changsha 410013, Hunan Province, China.
FAU - He, Hong-Hui
AU  - He HH
AD  - Department of Endocrinology, Third Xiangya Hospital, Central South University, 
      Changsha 410013, Hunan Province, China.
FAU - Zhao, Li-Ling
AU  - Zhao LL
AD  - Department of Endocrinology, Third Xiangya Hospital, Central South University, 
      Changsha 410013, Hunan Province, China.
FAU - Xie, Yan-Hong
AU  - Xie YH
AD  - Department of Endocrinology, Third Xiangya Hospital, Central South University, 
      Changsha 410013, Hunan Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Acute Coronary Syndrome/blood/diagnosis/*metabolism
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Coronary Angiography
MH  - Cytokines/blood/*metabolism
MH  - Echocardiography
MH  - Female
MH  - Glucose/*metabolism
MH  - *Glucose Intolerance
MH  - Heart Function Tests
MH  - Humans
MH  - Inflammation Mediators
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Th1 Cells/*metabolism
MH  - Th2 Cells/*metabolism
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - T-helper 1/T-helper 2 profile
OT  - impaired glucose tolerance
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest
EDAT- 2018/07/05 06:00
MHDA- 2018/10/31 06:00
CRDT- 2018/07/05 06:00
PHST- 2018/07/05 06:00 [entrez]
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
AID - JCanResTher_2018_14_9_480_194346 [pii]
AID - 10.4103/0973-1482.194346 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2018 Jun;14(Supplement):S480-S485. doi: 
      10.4103/0973-1482.194346.