PMID- 29970748
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 29
IP  - 3
DP  - 2018 May-Jun
TI  - A case report of successful renal transplantation in an ABO incompatible patient 
      with a preformed donor-specific antibody and negative CDC human leukocyte 
      antigens crossmatch.
PG  - 698-704
LID - 10.4103/1319-2442.235194 [doi]
AB  - ABO incompatibility and preformed antibodies against the human leukocyte antigen 
      (HLA) are two impermissible barriers to a successful renal transplantation, 
      especially in highly sensitized patient population. With the availability of 
      effective desensitization regimens, good patient and graft outcomes have been 
      reported. As transfusion medicine specialists we report our experience, where 
      patient presented with dual histocompatibility barriers i.e. ABO incompatibility 
      along with preformed donor-specific antibodies (DSA) and negative complement 
      dependent lymphocytotoxicity (CDC) HLA crossmatch. The desensitization strategy 
      followed for our patient included rituximab (375 mg/m(2)), bortezomib (1.3 
      mg/m(2)) and eleven pre-transplant therapeutic plasma exchange (TPE) followed by 
      intravenous immunoglobulin (100 mg/kg per TPE session). Anti-B titer of 1:1 and 
      negative Luminex crossmatch (LumXm) class II DSA (less than 1000 mean 
      fluorescence intensity; MFI), was achieved prior to renal transplantation. 
      Fifteen months post-transplant, patient is doing well with serum creatinine level 
      of 0.8 mg/dL with repeat LumXm class II DSA negative (891 MFI). The 
      desensitization regimen followed proved to be effective in our case.
FAU - Chowdhry, Mohit
AU  - Chowdhry M
AD  - Department of Transfusion Medicine, Indraprastha Apollo Hospital, New Delhi, 
      India.
FAU - Makroo, Raj Nath
AU  - Makroo RN
AD  - Department of Transfusion Medicine, Indraprastha Apollo Hospital, New Delhi, 
      India.
FAU - Kakkar, Brinda
AU  - Kakkar B
AD  - Department of Transfusion Medicine, Indraprastha Apollo Hospital, New Delhi, 
      India.
FAU - Jasuja, Sanjiv
AU  - Jasuja S
AD  - Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.
FAU - Sagar, Gaurav
AU  - Sagar G
AD  - Department of Nephrology, Indraprastha Apollo Hospital, New Delhi, India.
FAU - Thakur, Yogita
AU  - Thakur Y
AD  - Department of Transfusion Medicine, Indraprastha Apollo Hospital, New Delhi, 
      India.
LA  - eng
PT  - Case Reports
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (HLA Antigens)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adult
MH  - Desensitization, Immunologic/*methods
MH  - Female
MH  - Graft Survival
MH  - HLA Antigens/blood
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Immunologic Factors/therapeutic use
MH  - Kidney Transplantation/*methods
MH  - Plasmapheresis/methods
MH  - Tissue Donors
COIS- None declared
EDAT- 2018/07/05 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/07/05 06:00
PHST- 2018/07/05 06:00 [entrez]
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2018_29_3_698_235194 [pii]
AID - 10.4103/1319-2442.235194 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2018 May-Jun;29(3):698-704. doi: 
      10.4103/1319-2442.235194.