PMID- 29971797
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20200219
IS  - 1600-0684 (Electronic)
IS  - 0047-2565 (Print)
IS  - 0047-2565 (Linking)
VI  - 47
IP  - 6
DP  - 2018 Dec
TI  - Determination of major histocompatibility class I and class II genetic 
      composition of the Caribbean Primate Center specific pathogen-free rhesus macaque 
      (Macaca mulatta) colony based on massively parallel sequencing.
PG  - 379-387
LID - 10.1111/jmp.12353 [doi]
AB  - BACKGROUND: Knowledge of major histocompatibility complex (MHC) composition and 
      distribution in rhesus macaque colonies is critical for management strategies 
      that maximize the utility of this model for biomedical research. METHODS: 
      Variation within the Mamu-A and Mamu-B (class I) and DRB, DQA/B, and DPA/B (class 
      II) regions of 379 animals from the Caribbean Primate Research Center's (CPRC) 
      specific pathogen free (SPF) colony was examined using massively parallel 
      sequencing. RESULTS: Analyses of the 7 MHC loci revealed a background of Indian 
      origin with high levels of variation despite past genetic bottlenecks. All loci 
      exhibited mutual linkage disequilibria while conforming to Hardy-Weinberg 
      expectations suggesting the achievement of mutation-selection balance. 
      CONCLUSION: The CPRC's SPF colony is a significant resource for research on AIDS 
      and other infectious agents. Characterizing colony-wide MHC variability 
      facilitates the breeding and selection of animals bearing desired haplotypes and 
      increases the investigator's ability to understand the immune responses mounted 
      by these animals.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kanthaswamy, Sreetharan
AU  - Kanthaswamy S
AUID- ORCID: 0000-0003-4503-6886
AD  - California National Primate Research Center, University of California, Davis, CA, 
      USA.
AD  - School of Mathematics and Natural Sciences, Arizona State University (ASU) at the 
      West Campus, Glendale, AZ, USA.
FAU - Oldt, Robert F
AU  - Oldt RF
AD  - School of Mathematics and Natural Sciences, Arizona State University (ASU) at the 
      West Campus, Glendale, AZ, USA.
FAU - Ng, Jillian
AU  - Ng J
AD  - California National Primate Research Center, University of California, Davis, CA, 
      USA.
FAU - Smith, David Glenn
AU  - Smith DG
AD  - California National Primate Research Center, University of California, Davis, CA, 
      USA.
FAU - Martinez, Melween I
AU  - Martinez MI
AD  - Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences 
      Campus, San Juan, Puerto Rico.
FAU - Sariol, Carlos A
AU  - Sariol CA
AD  - Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences 
      Campus, San Juan, Puerto Rico.
AD  - Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical 
      Sciences Campus, San Juan, Puerto Rico.
AD  - Department of Medicine, University of Puerto Rico-Medical Sciences Campus, San 
      Juan, Puerto Rico.
LA  - eng
GR  - P40 OD012217/OD/NIH HHS/United States
GR  - P51 OD011107/OD/NIH HHS/United States
GR  - U42 OD011128/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20180704
PL  - Denmark
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Animals, Laboratory/genetics
MH  - *Gene Frequency
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Haplotypes
MH  - High-Throughput Nucleotide Sequencing
MH  - Macaca mulatta/*genetics
MH  - Puerto Rico
MH  - Specific Pathogen-Free Organisms
PMC - PMC6234078
MID - NIHMS971156
OTO - NOTNLM
OT  - Mamu haplotypes
OT  - colony genetic structure
OT  - genetic management
OT  - major histocompatibility complex genotyping
OT  - next generation sequence
EDAT- 2018/07/05 06:00
MHDA- 2019/10/15 06:00
PMCR- 2019/12/01
CRDT- 2018/07/05 06:00
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2018/07/05 06:00 [entrez]
PHST- 2019/12/01 00:00 [pmc-release]
AID - 10.1111/jmp.12353 [doi]
PST - ppublish
SO  - J Med Primatol. 2018 Dec;47(6):379-387. doi: 10.1111/jmp.12353. Epub 2018 Jul 4.