PMID- 29971938
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 41
IP  - 1
DP  - 2019 Feb
TI  - Recent advances in cytogenetic characterization of multiple myeloma.
PG  - 5-14
LID - 10.1111/ijlh.12882 [doi]
AB  - The detection of cytogenetic abnormalities in multiple myeloma (MM) has received 
      more importance over last years for risk stratification and the new risk-adapted 
      treatment strategies. Conventional G-banding analysis should be included in a 
      routine procedure for the initial diagnostic workup for patients suspected of MM. 
      However, the detection of chromosomal abnormalities in MM by conventional 
      cytogenetics is limited owing to the low proliferative activity of malignant 
      plasma cells as well as the low number of plasma cells in bone marrow specimens. 
      Fluorescence in situ hybridization (FISH) or microarray-based technologies can 
      overcome some of those drawbacks and detect specific target arrangements as well 
      as chromosomal copy number changes. In this review, we will discuss different 
      cytogenetic approaches and compare their strength and weakness to provide genetic 
      information for risk stratification and prediction of outcome in MM patients.
CI  - (c) 2018 John Wiley & Sons Ltd.
FAU - Saxe, Debra
AU  - Saxe D
AD  - Department of Pathology and Laboratory Medicine, Emory University School of 
      Medicine, Atlanta, Georgia.
FAU - Seo, Eul-Ju
AU  - Seo EJ
AD  - Department of Laboratory Medicine, College of Medicine and Asan Medical Center, 
      University of Ulsan, Seoul, Korea.
FAU - Bergeron, Melanie Beaulieu
AU  - Bergeron MB
AD  - Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, 
      ON, Canada.
AD  - Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON, 
      Canada.
FAU - Han, Jin-Yeong
AU  - Han JY
AUID- ORCID: 0000-0003-0280-2739
AD  - Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, 
      Korea.
LA  - eng
GR  - Dong-A University/
PT  - Journal Article
PT  - Review
DEP - 20180703
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
SB  - IM
MH  - Chromosome Aberrations
MH  - Cytogenetics/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/*genetics
MH  - Risk Assessment
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - chromosome abnormalities
OT  - cytogenetics
OT  - fluorescence in situ hybridization
OT  - microarray
OT  - multiple myeloma
EDAT- 2018/07/05 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/07/05 06:00
PHST- 2018/03/03 00:00 [received]
PHST- 2018/06/08 00:00 [accepted]
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/07/05 06:00 [entrez]
AID - 10.1111/ijlh.12882 [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2019 Feb;41(1):5-14. doi: 10.1111/ijlh.12882. Epub 2018 Jul 3.