PMID- 29972267
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20231019
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 39
IP  - 11
DP  - 2018 Nov
TI  - Clinical subcategorization of minimally conscious state according to resting 
      functional connectivity.
PG  - 4519-4532
LID - 10.1002/hbm.24303 [doi]
AB  - Patients in minimally conscious state (MCS) have been subcategorized in MCS plus 
      and MCS minus, based on command-following, intelligible verbalization or 
      intentional communication. We here aimed to better characterize the functional 
      neuroanatomy of MCS based on this clinical subcategorization by means of resting 
      state functional magnetic resonance imaging (fMRI). Resting state fMRI was 
      acquired in 292 MCS patients and a seed-based analysis was conducted on a 
      convenience sample of 10 MCS plus patients, 9 MCS minus patients and 35 healthy 
      subjects. We investigated the left and right frontoparietal networks (FPN), 
      auditory network, default mode network (DMN), thalamocortical connectivity and 
      DMN between-network anticorrelations. We also employed an analysis based on 
      regions of interest (ROI) to examine interhemispheric connectivity and 
      investigated intergroup differences in gray/white matter volume by means of 
      voxel-based morphometry. We found a higher connectivity in MCS plus as compared 
      to MCS minus in the left FPN, specifically between the left dorso-lateral 
      prefrontal cortex and left temporo-occipital fusiform cortex. No differences 
      between patient groups were observed in the auditory network, right FPN, DMN, 
      thalamocortical and interhemispheric connectivity, between-network 
      anticorrelations and gray/white matter volume. Our preliminary group-level 
      results suggest that the clinical subcategorization of MCS may involve functional 
      connectivity differences in a language-related executive control network. MCS 
      plus and minus patients are seemingly not differentiated by networks associated 
      to auditory processing, perception of surroundings and internal 
      awareness/self-mentation, nor by interhemispheric integration and structural 
      brain damage.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Aubinet, Charlene
AU  - Aubinet C
AUID- ORCID: 0000-0001-5095-5583
AD  - Coma Science Group, GIGA Research Center and Neurology Department, University and 
      University Hospital of Liege, Liege, Belgium.
FAU - Larroque, Stephen Karl
AU  - Larroque SK
AD  - Coma Science Group, GIGA Research Center and Neurology Department, University and 
      University Hospital of Liege, Liege, Belgium.
FAU - Heine, Lizette
AU  - Heine L
AD  - Auditory Cognition and Psychoacoustics Team - Lyon Neuroscience Research Center 
      (UCBL, CNRS UMR5292, Inserm U1028), Lyon, France.
FAU - Martial, Charlotte
AU  - Martial C
AD  - Coma Science Group, GIGA Research Center and Neurology Department, University and 
      University Hospital of Liege, Liege, Belgium.
FAU - Majerus, Steve
AU  - Majerus S
AD  - Psychology and Neuroscience of Cognition Research Unit, University of Liege, 
      Belgium.
FAU - Laureys, Steven
AU  - Laureys S
AD  - Coma Science Group, GIGA Research Center and Neurology Department, University and 
      University Hospital of Liege, Liege, Belgium.
FAU - Di Perri, Carol
AU  - Di Perri C
AUID- ORCID: 0000-0003-0284-770X
AD  - Coma Science Group, GIGA Research Center and Neurology Department, University and 
      University Hospital of Liege, Liege, Belgium.
AD  - Centre for Clinical Brain Sciences UK Dementia Research Institute, Centre for 
      Dementia Prevention, University of Edinburgh, Edinburgh, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180704
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Persistent Vegetative State/*classification/*diagnostic imaging/physiopathology
MH  - Preliminary Data
MH  - Rest
MH  - Young Adult
PMC - PMC6866360
OTO - NOTNLM
OT  - MCS minus and plus
OT  - auditory network
OT  - default mode network
OT  - frontoparietal network
OT  - functional connectivity
OT  - language
OT  - resting state fMRI
OT  - structural imaging
EDAT- 2018/07/05 06:00
MHDA- 2019/06/14 06:00
PMCR- 2018/07/04
CRDT- 2018/07/05 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2018/05/15 00:00 [revised]
PHST- 2018/06/20 00:00 [accepted]
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/07/05 06:00 [entrez]
PHST- 2018/07/04 00:00 [pmc-release]
AID - HBM24303 [pii]
AID - 10.1002/hbm.24303 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2018 Nov;39(11):4519-4532. doi: 10.1002/hbm.24303. Epub 2018 Jul 
      4.