PMID- 29972653
OWN - NLM
STAT- MEDLINE
DCOM- 20200505
LR  - 20200701
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 39
IP  - 7
DP  - 2019 Jul
TI  - Preconditioning with partial caloric restriction confers long-term protection 
      against grey and white matter injury after transient focal ischemia.
PG  - 1394-1409
LID - 10.1177/0271678X18785480 [doi]
AB  - Caloric restriction (CR) has been extensively examined as a preventative strategy 
      against aging and various diseases, but CR effects on cerebral ischemia are 
      largely unknown. We subjected C57BL6/J mice to ad libitum food access (LF) or a 
      diet restricted to 70% of ad libitum food access (RF) for two to four weeks 
      followed by 60 min of transient focal ischemia (tFCI). RF for four weeks 
      protected against subsequent tFCI-induced infarct. RF improved sensorimotor 
      function after stroke in the foot fault and corner tests, as well as performance 
      in the Morris water maze test. In addition, RF preserved ischemic white matter 
      tract integrity assessed by histology and compound action potential. Sirt1 and 
      Sirt3 were both upregulated in RF ischemic brain, but heterozygous deletion of 
      Sirt1 or knockout of Sirt3 did not alter the protection induced by RF against 
      ischemic injury. RF induced significant release of adiponectin, a hormone related 
      to glucose metabolism. Knockout of adiponectin decreased RF-induced protection 
      after tFCI. These data demonstrate the novel finding that white matter, as well 
      as neurons, benefit from CR prior to cerebral ischemic injury, and that 
      adiponectin may contribute to these protective effects.
FAU - Zhang, Jia
AU  - Zhang J
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Zhang, Wenting
AU  - Zhang W
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Gao, Xuguang
AU  - Gao X
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Zhao, Yongfang
AU  - Zhao Y
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Chen, Di
AU  - Chen D
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Xu, Na
AU  - Xu N
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
AD  - 2 Pittsburgh Institute for Brain Disease and Recovery (PIBDR) and the Department 
      of Neurology, University of Pittsburgh, Pittsburgh PA, USA.
FAU - Pu, Hongjian
AU  - Pu H
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
AD  - 2 Pittsburgh Institute for Brain Disease and Recovery (PIBDR) and the Department 
      of Neurology, University of Pittsburgh, Pittsburgh PA, USA.
FAU - Stetler, R Anne
AU  - Stetler RA
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
FAU - Gao, Yanqin
AU  - Gao Y
AD  - 1 State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, 
      Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 
      China.
AD  - 2 Pittsburgh Institute for Brain Disease and Recovery (PIBDR) and the Department 
      of Neurology, University of Pittsburgh, Pittsburgh PA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180704
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Adiponectin)
RN  - 0 (Receptors, Adiponectin)
RN  - 0 (adiponectin receptor 1, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - EC 3.5.1.- (Sirtuin 3)
SB  - IM
MH  - Adiponectin/genetics/physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Ischemic Attack, Transient/pathology/physiopathology/*prevention & control
MH  - Ligation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Middle Cerebral Artery/surgery
MH  - Neuroprotection
MH  - Receptors, Adiponectin/analysis
MH  - Sensorimotor Cortex/pathology/physiopathology
MH  - Sirtuin 1/genetics/physiology
MH  - Sirtuin 3/genetics/physiology
MH  - White Matter/chemistry/pathology/physiopathology
PMC - PMC6668518
OTO - NOTNLM
OT  - Adiponectin
OT  - caloric restriction
OT  - cerebral ischemia
OT  - sirtuin
OT  - stroke
EDAT- 2018/07/05 06:00
MHDA- 2020/05/06 06:00
PMCR- 2020/07/01
CRDT- 2018/07/05 06:00
PHST- 2018/07/05 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2018/07/05 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1177_0271678X18785480 [pii]
AID - 10.1177/0271678X18785480 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2019 Jul;39(7):1394-1409. doi: 
      10.1177/0271678X18785480. Epub 2018 Jul 4.