PMID- 29974600
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20190103
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 44
IP  - 9
DP  - 2018 Sep
TI  - 47-Fold rise of diabetes in childbearing age Chilean women: Markov model and 
      cost-effectiveness of prevention of birth defects.
PG  - 1719-1730
LID - 10.1111/jog.13712 [doi]
AB  - AIM: Prevalence of type 2 diabetes mellitus (T2DM) during childbearing age in 
      Chile had a 47-fold rise in 7 years, reaching 120 844 women, half of which are 
      unaware of their condition. We aimed to project pregnancies and births among 
      Chilean women of childbearing age (WCBA) with T2DM and report the incidence of 
      birth defects and the associated years of life lost and lifetime costs. METHODS: 
      Markov model of cohort of WCBA with T2DM (WCBA-DM) with a 20-year time horizon 
      (2018-2037), using data from previous studies. Two scenarios were assessed: 
      scenario A: no universal detection of T2DM and scenario B: universal screening of 
      T2DM using glycosylated hemoglobin levels. Both lifetime costs and 
      disability-adjusted life years (DALY) were calculated with a 5% discount rate 
      (US$ of 2017). RESULTS: In scenario A, 12 163 infants with birth defects could be 
      born among the analyzed cohort, resulting in 243 260 years of life lost, 296 652 
      DALY and in lifetime costs of US$ 1 957 657 966. In scenario B, the first three 
      figures could be reduced by 70.4% to 3599 infants with birth defects, 71 980 
      years of life lost and 87 794 DALY. Due to the addition of diabetes screening and 
      new patient costs to scenario B, there would be a lesser reduction (67.3%) in 
      total lifetime costs, to US$ 640 669 296. CONCLUSION: Screening of diabetes in 
      WCBA would yield a 20-year reduction of 70.4% in the number of infants with birth 
      defects, years of life lost and DALY. Total lifetime costs could be reduced by 
      67.3%.
CI  - (c) 2018 Japan Society of Obstetrics and Gynecology.
FAU - Olmos, Pablo
AU  - Olmos P
AD  - First Center of Biomedical Engineering, College of Medicine, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
AD  - Trinidad Initiative, College of Medicine, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
AD  - Department of Obstetrics and Gynecology, College of Medicine, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
AD  - Department of Nutrition, Diabetes and Metabolism, College of Medicine, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
FAU - Borzone, Gisella
AU  - Borzone G
AD  - Department of Respiratory Diseases, College of Medicine, Pontificia Universidad 
      Catolica de Chile, Santiago, Chile.
FAU - Poblete, Andres
AU  - Poblete A
AD  - Department of Obstetrics and Gynecology, College of Medicine, Pontificia 
      Universidad Catolica de Chile, Santiago, Chile.
LA  - eng
PT  - Journal Article
DEP - 20180705
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chile/epidemiology
MH  - Congenital Abnormalities/*epidemiology/*prevention & control
MH  - *Cost-Benefit Analysis
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Markov Chains
MH  - *Mass Screening
MH  - Middle Aged
MH  - *Models, Statistical
MH  - Young Adult
OTO - NOTNLM
OT  - Markov
OT  - diabetes
OT  - malformation
OT  - model
OT  - pregestational
OT  - prevention
EDAT- 2018/07/06 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/07/06 06:00
PHST- 2017/10/18 00:00 [received]
PHST- 2018/05/25 00:00 [accepted]
PHST- 2018/07/06 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2018/07/06 06:00 [entrez]
AID - 10.1111/jog.13712 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2018 Sep;44(9):1719-1730. doi: 10.1111/jog.13712. Epub 
      2018 Jul 5.