PMID- 29977615
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2018
DP  - 2018
TI  - Association of Genes in the High-Density Lipoprotein Metabolic Pathway with 
      Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and 
      Meta-Analysis.
PG  - 9538671
LID - 10.1155/2018/9538671 [doi]
LID - 9538671
AB  - PURPOSE: To assess the association of genes in the high-density lipoprotein 
      metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the 
      genetic difference in the HDLMP between PCV and age-related macular degeneration 
      (AMD). METHODS: We performed a literature search in EMBASE, PubMed, and Web of 
      Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 
      genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic 
      lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 
      (ABCA1), and ATP-binding cassette transporter G1 (ABCG1) in PCV. All studies were 
      published before September 30, 2017, without language restriction. Pooled odds 
      ratios (ORs) and 95% confidence intervals (CIs) of each polymorphism were 
      estimated. We also compared the association profiles between PCV and AMD and 
      performed a sensitivity analysis. RESULTS: Our result is based on 43 articles. 
      After excluding duplicates and articles without complete information, 7 studies 
      were applicable to meta-analysis. 7 polymorphisms were meta-analyzed: CETP 
      rs2303790/rs3764261, LIPC rs10468017/rs493258, LPL rs12678919, ABCA1 rs1883025, 
      and ABCG1 rs57137919. We found that in Asian population, CETP rs3764261 (T 
      allele; OR = 1.46; 95% CI: 1.28-1.665, P < 0.01), CETP rs2303790 (G allele; 
      OR = 1.57; 95% CI: 1.258-1.96, P < 0.01), and ABCG1 rs57137919 (A allele; 
      OR = 1.168; 95% CI: 1.016-1.343, P < 0.01) were significantly associated with 
      PCV, and ABCG1 rs57137919 (A allele; OR = 1.208, 95% CI: 1.035-1.411, P < 0.01) 
      has different effects in PCV and AMD. The other 4 polymorphisms in LIPC/LPL/ABCA1 
      had no significant association with PCV (P > 0.05). The sensitivity analysis 
      validated the significance of our analysis. CONCLUSIONS: Our study revealed 7 
      polymorphisms in 5 genes. Among them, CETP (rs3764261/rs2303790) and ABCG1 
      (rs57137919) were the major susceptibility genes for PCV in Asian population and 
      ABCG1 (rs57137919) showed allelic diversity between PCV and AMD. Since the size 
      for PCV and AMD was small, we need to study these genes genotyping in larger 
      samples.
FAU - Yuan, Ming-Zhen
AU  - Yuan MZ
AD  - Department of Ophthalmology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Han, Ruo-An
AU  - Han RA
AD  - Department of Ophthalmology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Zhang, Chen-Xi
AU  - Zhang CX
AD  - Department of Ophthalmology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Chen, You-Xin
AU  - Chen YX
AUID- ORCID: 0000-0001-7275-6067
AD  - Department of Ophthalmology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180606
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC6011074
EDAT- 2018/07/07 06:00
MHDA- 2018/07/07 06:01
PMCR- 2018/06/06
CRDT- 2018/07/07 06:00
PHST- 2017/11/18 00:00 [received]
PHST- 2018/03/29 00:00 [accepted]
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/07 06:01 [medline]
PHST- 2018/06/06 00:00 [pmc-release]
AID - 10.1155/2018/9538671 [doi]
PST - epublish
SO  - J Ophthalmol. 2018 Jun 6;2018:9538671. doi: 10.1155/2018/9538671. eCollection 
      2018.