PMID- 29977652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 9
DP  - 2018 Jan-Dec
TI  - Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced 
      allergic rhinitis in the mouse.
PG  - 2152656718764145
LID - 10.1177/2152656718764145 [doi]
LID - 2152656718764145
AB  - BACKGROUND: Wogonin is commonly used for the treatment of allergic diseases. 
      However, neither its precise effect in preventing allergic rhinitis (AR) nor its 
      mechanism of action are known. OBJECTIVES: In this study, the effect of wogonin 
      on allergic responses in ovalbumin (OVA) induced AR was investigated in mice. 
      METHODS: BALB/c mice were sensitized with intraperitoneal (i.p.) OVA and then 
      challenged intranasally with OVA. Wogonin (10 and 30 mg/kg) was given to the 
      treatment groups, and the effect of wogonin on the release of allergic 
      inflammatory mediators, specifically OVA-specific immunoglobulin E (IgE) and 
      inflammatory cytokines, was explored. Eosinophil infiltration and the levels of 
      interleukin (IL) 5 and IL-13 were measured by immunohistochemistry. RESULTS: In 
      mice with AR, wogonin decreased OVA-specific IgE levels in serum, and the levels 
      of the cytokines IL-4, IL-5, IL-13, eotaxin, and RANTES in nasal lavage fluid. 
      Serum levels of IL-4, IL-5, and IL-13 were lower in both groups of 
      wogonin-pretreated mice than in the OVA group. A reduction in eosinophil 
      infiltration of the nasal mucosa and inhibition of the expression of IL-5 and 
      IL-13 were also noted in the treated groups. CONCLUSION: Wogonin induced 
      antiallergic effects in a murine model of AR by decreasing the infiltration of 
      eosinophils and levels of T-helper type 2 cytokines. Thus, wogonin merits 
      consideration as a therapeutic agent for treating AR.
FAU - Kim, Kyeong Ah
AU  - Kim KA
AD  - Department of Otolaryngology-Head and Neck Surgery, Gachon University Gil Medical 
      Center, Incheon, Korea.
AD  - This work was supported by the Gachon University Gil Medical Center (Grant 
      Number: 2014-33).
AD  - K. Ah Kim and J.H. Jung contributed equally to this work.
AD  - The authors have no conflicts of interest to declare pertaining to this article.
FAU - Jung, Joo Hyun
AU  - Jung JH
AD  - Department of Otolaryngology-Head and Neck Surgery, Gachon University Gil Medical 
      Center, Incheon, Korea.
AD  - This work was supported by the Gachon University Gil Medical Center (Grant 
      Number: 2014-33).
AD  - K. Ah Kim and J.H. Jung contributed equally to this work.
AD  - The authors have no conflicts of interest to declare pertaining to this article.
FAU - Choi, Yun Sook
AU  - Choi YS
AD  - Department of Otolaryngology-Head and Neck Surgery, Gachon University Gil Medical 
      Center, Incheon, Korea.
AD  - This work was supported by the Gachon University Gil Medical Center (Grant 
      Number: 2014-33).
AD  - K. Ah Kim and J.H. Jung contributed equally to this work.
AD  - The authors have no conflicts of interest to declare pertaining to this article.
FAU - Kang, Gyu
AU  - Kang G
AD  - Department of Otolaryngology-Head and Neck Surgery, Gachon University Gil Medical 
      Center, Incheon, Korea.
AD  - This work was supported by the Gachon University Gil Medical Center (Grant 
      Number: 2014-33).
AD  - K. Ah Kim and J.H. Jung contributed equally to this work.
AD  - The authors have no conflicts of interest to declare pertaining to this article.
FAU - Kim, Seon Tae
AU  - Kim ST
AD  - Department of Otolaryngology-Head and Neck Surgery, Gachon University Gil Medical 
      Center, Incheon, Korea.
AD  - This work was supported by the Gachon University Gil Medical Center (Grant 
      Number: 2014-33).
AD  - K. Ah Kim and J.H. Jung contributed equally to this work.
AD  - The authors have no conflicts of interest to declare pertaining to this article.
LA  - eng
PT  - Journal Article
DEP - 20180409
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC6028163
EDAT- 2018/07/07 06:00
MHDA- 2018/07/07 06:01
PMCR- 2018/04/09
CRDT- 2018/07/07 06:00
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/07 06:01 [medline]
PHST- 2018/04/09 00:00 [pmc-release]
AID - 10.1177_2152656718764145 [pii]
AID - 10.1177/2152656718764145 [doi]
PST - epublish
SO  - Allergy Rhinol (Providence). 2018 Apr 9;9:2152656718764145. doi: 
      10.1177/2152656718764145. eCollection 2018 Jan-Dec.