PMID- 29977960
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 5
IP  - 6
DP  - 2018 Jun
TI  - Pneumococcal Conjugate Vaccine Safety in Elderly Adults.
PG  - ofy100
LID - 10.1093/ofid/ofy100 [doi]
LID - ofy100
AB  - BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV13) and the 
      23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to 
      adults aged >/=65 years. The study examines adults >/=65 years for risk of adverse 
      events (AEs) requiring medical attention following vaccination with PCV13 as 
      compared with vaccination with PPSV23, a long-standing vaccine with a 
      satisfactory safety profile. METHODS: The cohort study included 6 Vaccine Safety 
      Datalink sites. The exposed person-time included follow-up time of the first 
      PCV13 received by subjects age >/=65 years from January 1 to August 15, 2015. The 
      comparator person-time included follow-up time after the first PPSV23 received by 
      subjects of the same age during Janaury 1 to August 15 of each year of 2011-2015. 
      The prespecified AEs included cardiovascular events, Bell's palsy, Guillain-Barre 
      syndrome, syncope, erythema multiforme, thrombocytopenia, cellulitis and 
      infection, allergic reaction, and anaphylaxis. Inverse probability of treatment 
      weighting-adjusted Poisson regression models was used to estimate the relative 
      risk (RR) of each AE. RESULTS: A total of 313 136 doses of PCV13 and 232 591 
      doses of PPSV23 were included. The adjusted RRs comparing the incidence of AEs 
      following PCV13 vs PPSV23 were all <1, except for anaphylaxis, which was 
      insignificant with an RR of 1.32 (95% confidence interval, 0.30-5.79). Only 1 
      patient who received PCV13 and 4 other vaccines concomitantly was confirmed by 
      medical chart review as having experienced anaphylaxis after vaccination. 
      CONCLUSIONS: These data do not support an increased rate of adverse events 
      following PCV13 administration in elders compared with PPSV23 and should provide 
      reassurance regarding continued use of PCV13.
FAU - Tseng, Hung Fu
AU  - Tseng HF
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Sy, Lina S
AU  - Sy LS
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Qian, Lei
AU  - Qian L
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Liu, In-Lu A
AU  - Liu IA
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Mercado, Cheryl
AU  - Mercado C
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Lewin, Bruno
AU  - Lewin B
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Tartof, Sara Y
AU  - Tartof SY
AD  - Kaiser Permanente, Pasadena, Southern California.
FAU - Nelson, Jennifer
AU  - Nelson J
AD  - Kaiser Permanente, Seattle, Washington.
FAU - Jackson, Lisa A
AU  - Jackson LA
AD  - Kaiser Permanente, Seattle, Washington.
FAU - Daley, Matthew F
AU  - Daley MF
AD  - Kaiser Permanente, Denver, Colorado.
FAU - Weintraub, Eric
AU  - Weintraub E
AD  - Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, 
      Georgia.
FAU - Klein, Nicola P
AU  - Klein NP
AD  - Kaiser Permanente, Oakland, Northern California.
FAU - Belongia, Edward
AU  - Belongia E
AD  - Marshfield Clinic Research Institute, Marshfield, Wisconsin.
FAU - Liles, Elizabeth G
AU  - Liles EG
AD  - Kaiser Permanente, Northwest, Portland, Oregon.
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
AD  - Kaiser Permanente, Pasadena, Southern California.
LA  - eng
PT  - Journal Article
DEP - 20180502
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC6016414
OTO - NOTNLM
OT  - adult vaccination
OT  - adverse events
OT  - pneumococcal conjugate vaccine
EDAT- 2018/07/07 06:00
MHDA- 2018/07/07 06:01
PMCR- 2018/05/02
CRDT- 2018/07/07 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2018/05/01 00:00 [accepted]
PHST- 2018/07/07 06:00 [entrez]
PHST- 2018/07/07 06:00 [pubmed]
PHST- 2018/07/07 06:01 [medline]
PHST- 2018/05/02 00:00 [pmc-release]
AID - ofy100 [pii]
AID - 10.1093/ofid/ofy100 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2018 May 2;5(6):ofy100. doi: 10.1093/ofid/ofy100. 
      eCollection 2018 Jun.